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Sequential Hemodynamic Change in Hepatocellular Carcinoma and Dysplastic Nodule: CT Angiography and Pathologic Correlation

Research Project

Project/Area Number 11670899
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

AIBE Hitoshi  Graduate School of Medical Sciences, Kyushu University Research Ass., 大学院・医学研究院, 助手 (40304810)

Co-Investigator(Kenkyū-buntansha) IRIE Hiroyuki  Faculty of Medicine, Kyushu University Research Ass., 医学部・附属病院, 助手 (50284493)
YOSHIMITSU Kengo  Faculty of Medicine, Kyushu University Research Ass., 医学部・附属病院, 助手 (20274467)
HONDA Hiroshi  Graduate School of Medical Sciences, Kyushu University Assoc. Prof., 大学院・医学研究院, 助教授 (90145433)
田嶋 強  九州大学, 医学部, 医員
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2000: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
KeywordsHepatocellular carcinoma / CTAP / CTA / Angiogenesis / Angiogenesis
Research Abstract

The purpose of this study was to clarify the hemodynamic changes associated with hepatocarcinogenesis using CT angiography. Eighty-six hepatocellular lesions in 49 patients who underwent CT with both hepatic arteriography and arterioportography were pathologically confirmed. These images were compared with lesion-to-liver vascular ratios of cumulative arteries, preexisting hepatic arteries, and portal veins in resected specimens. Lesions were classified into five groups according to intranodular hemodynamics determined by CT hepatic arteriography and CT during arterioportography; group 1: isoattenuating on both; group 2: hypoattenuating on CT hepatic arteriography and isoattenuating on CT during arterioportography; group 3: hypoattenuating on both; group 4: isoattenuating on CT hepatic arteriography and hypoattenuating on CT during arterioportography; and group 5: hyperattenuating on CT hepatic arteriography and hypoattenuating on CT during arterioportography. .Among 86 lesions, there were 7 low-grade dysplastic nodules, 8 high-grade dysplastic nodules, 14 well-differentiated hepatocellular carcinomas, 45 moderately differentiated hepatocellular carcinomas, and 12 poorly differentiated hepatocellular carcinomas. The lesions were classified into group 1 (n=5), group 2 (n=13), group 3 (n=6), group 4 (n=2), and group 5 (n=60). Intranodular hemodynamics was significantly correlated with pathologic gradings (p<.001). For correlations between combinations of the groups and patnologic gradings, the order "groups 1-2-3-4-5" was the most significant (p<.001). During hepatocarcinogenesis, most hepatocellular nodules show deterioration of arterial blood flow before loss of portal blood flow. Vascular imaging of hepatic nodules may predict malignant pathology via the early loss of hepatic arterial flow prior to portal flow changes.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Honda H, Tajima T, Kajiyama K, Kuroiwa T, Yoshimitsu K, Irie H, Aibe H, Shimada M, Masuda K: "Vascular changes in hepatocellular carcinoma : correlation of radiologic and pathologic findings"American Journal of Roentgenology. 173・5. 1213-1217 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Honda H, Tajima T, Taguchi K, Kuroiwa T, Yoshimitsu K, Irie H, Aibe H, Shinozaki K, Asayama Y, Shimada M, Masuda K: "Recent development in imaging diagnostics for HCC : CT arteriography and CT arterioportography evaluation of vascular changes in premalignant and malignant hepatic nodules"J Hepatobiliary Pancreat Surg. 7・3. 245-251 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tajima T, Honda H, Taguchi K, Asayama Y, Kuroiwa T, Yoshimitsu K, Irie H, Aibe H, Shimada M, Masuda K: "Sequential hemodynamic change in hepatocellular carcinoma and dysplastic nodule : CT angiography and pathologic correlation"American Journal of Roentgenology. 178・47(In press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Honda H, Tajima T, Kajiyama K, Kuroiwa T, Yoshimitsu K, Irie H, Aibe H, Shimada M, Masuda K: "Vascular changes in hepatocellular carcinoma: correlation of radiologic and pathologic findings"American Journal of Roentgenology. 173・5. 1213-1217 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Honda H, Tajima T, Taguchi K, Kuroiwa T, Yoshimitsu K, Irie H, Aibe H, Shinozaki K, Asayama Y, Shimada M, Masuda K: "Recent development in imaging diagnostics for HCC: CT arteriography and CT arterioportography evaluation of vascular changes in premalignant and malignant hepatic nodules"J Hepatobiliary Pancreat Surg. 7・3. 245-251 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tajima T, Honda H, Taguchi K, Asayama Y, Kuroiwa T, Yoshimitsu K, Irie H, Aibe H, Shimada M, Masuda K: "Sequential hemodynamic change in hepatocellular carcinoma and dysplastic nodule: CT angiography and pathologic correlation"American Journal of Roentgenology. 178・4 (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tajima T, Honda H, Taguchi K, Asayama Y, Kuroiwa T, Yoshimitsu K, Irie H, Aibe H, Shimada M, Masuda K: "Sequential hemodynamic change on hepatocellular carcinoma and dysplastic nodule : CT angiography and pathologic correlation"American Journal of Roentgenology. 178(4)(In press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Honda H,Tajima T,Tanguchi K,Kuroiwa T,Yoshimitsu K,Irie H,Aibe H, et al: "Recenet development in imaging diagnostics for HCC : CT arteriography and CT arterioportography evaluation of vascular changes in premalignant and malignant hepatic nodules"J Hepatobiliary Pancreat Surg. 7・3. 245-251 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Honda,H.Aibe,K.Yoshimitsu,T.Tajima,et al.: "Vascular changes in hepatocellular carcinoma : correlation of radiologic and pathologic findings"American Journal of Roentgenology. 173. 1213-1217 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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