| Project/Area Number |
11670920
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kansai Medical University |
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Principal Investigator |
IMAMURA Masahiro KANSAI MEDICAL UNIVERSITY, FUCULTY OF MEDICINE ASSISTANT PROFESSOR, 医学部, 助手 (40268339)
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| Co-Investigator(Kenkyū-buntansha) |
SAWADA Satoshi KANSAI MEDICAL UNIVERSITY, FUCULTY OF MEDICINE PROFESSOR, 医学部, 教授 (80121937)
NAGTA Kenji KANSAI MEDICAL UNIVERSITY, FUCULTY OF MEDICINE ASSISTANT PROFESSOR, 医学部, 助手 (30247928)
AKAGI Kiyoshi KANSAI MEDICAL UNIVERSITY, FUCULTY OF MEDICINE ASSISTANT PROFESSOR, 医学部, 講師 (30098115)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | heavy particle rays / Deinococcus radiodurants / hyperthermia / 突然変異 / プラスミドDNA |
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| Research Abstract |
Cells of the prokaryote D.radiodurans were used to simulate the cancer cell ; they grow quickly, are easy to handle, and are resistant to radiation and heat. Various modifications or combinations of hyperthermia and radiation in common use for cancer treatment were employed to effectively kill the D.radiodurans cells. Using acid heating, the cells were effectively killed. The mechanism was assumed to be on depurination of DNA.Even the cells showing resistance to a combination of hyperthermia and gamma irradiation were killed by the synergetic, cytotoxic, effect of a combination of hyperthermia and Alfa irradiation. In an attempt to find an effective combination of hyperethermia and other heavy particle rays, a preliminary experiment was conducted to assess the effects of the heavy particle rays. As a result, the killing mechanism was found to be dry and wet cells.
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