| Project/Area Number |
11670925
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
|
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| Research Institution | HOKKAIDO UNIVERSITY |
|---|
Principal Investigator |
ABEKAWA Tomohiro Hokkaido Univ., Grad. School of Medicine, Assistant Professor, 医学部・附属病院, 助手 (80301901)
|
|---|
| Project Period (FY) |
1999 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | METHAMPHETAMINE / PHENCYCLIDINE / SENSITIZATION / GLUTAMATE / GABA / MS-153 / 覚醒剤 / 行動感作 / dopamine / 神経回路網 |
|---|
| Research Abstract |
A novel compound, MS-153, which has an ability to enhance glutamate uptake and inhibit glutamate release, blocked the development of behavioral sensitization to locomotion-inducing effect of methamphetamine. Further, MS-153 blocked the development of sensitization not only to locomotion-but also stereotypy-inducing effect of phencyclidine. These results indicate that methamphetamine- or phencyclidine-inducing enhancement of glutamatergic neurotransmission can play an important role for developing behavioral sensitization to methamphetamine, or phencyclidine, respectively.
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