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Analyses of Pathophysiology and Development of Treatment Strategies in Late-Life Refractory Depression.

Research Project

Project/Area Number 11670926
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionTohoku University

Principal Investigator

AWATA Shuichi  Tohoku University, Hospital, Lecturer, 医学部・附属病院, 講師 (90232082)

Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsRefractory Depression / Late Life / Electroconvusivetherapy / SPECT / Paralimbic / Anterior Cingulate / Serotonin Transporter / Relapse / 維持治療 / 局所脳血液パターン / うつ病 / ECT / 局所脳血流 / 難治性 / 治療抵抗性 / 再発
Research Abstract

1. We investigated the short-term response rates of ECT in consecutive 16 patients with late-life refractory depression and 6-month relapse rates in 13 patients following response to ECT.Short-term response rate was 81% and 6-month relapse rate was 46%.
2. Using ^<99m>Tc-HMPAO SPECT, we examined the changes of rCBF patterns in nine late-life patients with major depressive episodes before and following response to ECT A mean rCBF was significantly decreased in the patients before ECT compared with the control, significantly increased (normalized) in the patients 2 weeks after ECT compared with that before ECT, and still increased in the patients 12 weeks after ECT compared with that before ECT.However, a significant rCBF reduction was found in the bilateral pre- and subcallosal anterior cingulate cortex, the bilateral caudal orbitofrontal cortex, the right insular cortex and the right posterior middle frontal gyrus in patients before ECT compared with the control, and similar rCBF patterns were shown at 2 weeks and 12 weeks after ECT.A mean rCBF reduction may have a state-related property while persistent anterior paralimbic hypoperfusion may have a trait-related property in late-life depression referred for ECT.
3. We investigated the effects of acute and chronic ECS on 5-HT transporter mRNA expression in rat raphe nucleus. 5-HTT mRNA expression was decreased 9, 24 hours after acute ECS and 3, 9, 24 hours and 2 weeks after chronic ECS in rat raphe nucleus. We presume that the adaptive change in 5-HTT mRNA expression is possibly related to the therapeutic efficacy of ECT on medication-resistant depression.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (39 results)

All Other

All Publications (39 results)

  • [Publications] Awata S.: "Vulnerability of late-life depression : As viewd from the effect of electroconvulsive therapy on regional cerebral blood flow."Psychiatry Clin.Neurosci.. 53. S86 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shen H, Awara S, ef al.: "The effect of ECT on platelet 3H-paroxetine binding in antidepressant-resistant depression."Psychiatry Clin.Neurosci.. 53. S110 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 沈昊偉,粟田主一,ほか: "老年期治療抵抗性うつ病に対する無けいれん電撃療法の奏効機序に関する研究(2)治療前後の血小板[3H]paroxetine結合の変化."精神神経系薬物療法研究基金研究年報. 31. 118-124 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 鈴木一正、粟田主一,ほか: "m-ECT(修正電気けいれん療法)後に繰り返し再燃するうつ病に継続ECTとlithium carbonateによる維持薬物治療が有効であった一例."精神科治療学. 15. 647-653 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 粟田主一、ほか: "電気けいれん療法後のうつ病の再燃脆弱性と局所脳血流動態の変化."精神神経系薬物療法研究基金研究年報. 32. 266-273 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 粟田主一: "老年期のうつ病と幻覚妄想病の治療とケア"日本老年医学会雑誌. 37. 882-884 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 粟田主一: "難治性感情傷害の治療におけるECT"Central Nervous System Today-3. 感情障害、不安障害、睡眠障害、分裂病-基礎から臨床まで.(加藤進昌、樋口輝彦編). 7-11 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suzuki K, Awata S, et al.: "Three cases treated by continuation/maintenance electroconvulsive therapy."Psychiatry Clin.Neurosci.. 54. S17 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shen H, Awata S, et al.: "Electroconvulsive shock regulates serotonin transporter mRNA expression in rat raphe nucleus."Psychiatry Clin.Neurosci.. 54. S34 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 沈昊偉,粟田主一,ほか: "電気けいれんショックによるラット脳内セロトニントランスポーター発現の変化"精神神経系薬物療法研究基金研究年報. 32(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 鈴木一正、粟田主一,ほか: "緊張病症候群を呈する遅発性精神病の一例."精神医学. 43(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shen H, Awata S, et al.: "ECS Regulates Serotonin Transporter mRNA Expression in Rat Raphe Nucleus."Psychiatry Clin.Neurosci.. 55(in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 島袋仁、粟田主一,ほか: "脳波上三相波を示したセロトニン症候群の一例"臨床精神医学. 30(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Awata S.: "Vulnerability of late-life depression : As viewd from the effect of electroconvulsive therapy on regional cerebral blood flow."Psychiatry Clin. Neurosci.. 53 (Abstract). S86 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shen H, Awata S, Konno M, Toyoda H, Ito C, Numachi Y, Sato M.: "The effect of ECT on platelet 3H-paroxetine binding in antidepressant-resistant depression."Psychiatry Clin. Neurosci. 53 (Abstract). S110 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suzuki K, Awata S, Ohara A, Yamashita Y, Kato N, Sato T, Sato M: "Three cases treated by continuation/maintenance electroconvulsive therapy."Psychiatry Clin. Neurosci.. 54 (Abstract). S17 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shen H, Numachi Y, Yoshida S, Toda S, Awata S, Matsuoka H, Sato M: "Electroconvulsive shock regulates serotonin transporter mRNA expression in rat raphe nucleus."Psychiatry Clin. Neurosci.. 54 (Abstract). S34 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suzuki K, Awata S, Ohara A, Sato T, Sato M.: "A case report of recurrent major depressive disorder successfully prevented from post-ECT relapse using continuation electroconvulsive therapy and lithium carbonate medication."Japanese Journal of Psychiatric Treatment. 15. 647-653 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Awata S: "Treatment and care for depression and delusion in late life."Jpn. J.Geriat.. 37. 882-884 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shen H, Numachi Y, Yoshida S, Toda S, Awata S, Matsuoka H, Sato M: "ECS Regulates Serotonin Transporter mRNA Expression in Rat Raphe Nucleus."Psychiatry Clin Neurosci. 55 (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Awata S, Suzuki K, Shen H, Sato M, Kawashima R, Fukuda H: "Relapse vulnerability and changes in regional cerebral blood flow in patients with depression after electroconvulsive therapy."Ann. Rep. Welfide Medicinal Res. Found.. 32. 266-273 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Awata S.: "Vulnerability of late-life depression : As viewd from the effect of electroconvulsive therapy on regional cerebral blood flow."Psychiatry Clin.Neurosci.. 53. S86 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shen H.Awata S, et al.: "The effect of ECT on platelet 3H-paroxetine binding in antidepressant-resistant depression."Psychiatry Clin.Neurosci.. 53. S110 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 沈昊偉,粟田主一 ほか: "老年期治療抵抗性うつ病に対する無けいれん電撃療法の奏効機序に関する研究(2)治療前後の血小板[3H]paroxetine結合の変化."精神神経系薬物療法研究基金研究年報. 31. 118-124 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 鈴木一正,粟田主一 ほか: "m-ECT(修正電気けいれん療法)後に繰り返し再燃するうつ病に継続ECTとlithium carbonateによる維持薬物治療が有効であった一例."精神科治療学. 15. 647-653 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 粟田主一 ほか: "電気けいれん療法後のうつ病の再燃脆弱性と局所脳血流動態の変化."精神神経系薬物療法研究基金研究年報. 32. 266-273 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 粟田主一: "老年期のうつ病と幻覚妄想病の治療とケア"日本老年医学会雑誌. 37. 882-884 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Suzuki K,Awata S, et al.: "Three cases treated by continuation/maintenance electroconvulsive therapy."Psychiatry Clin.Neurosci.. 54. S17 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shen H,Awata S, et al.: "Electroconvulsive shock regulates serotonin transporter mRNA expression in rat raphe nucleus."Psychiatry Clin.Neurosci.. 54. S34 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 沈昊偉,粟田主一 ほか: "電気けいれんショックによるラット脳内セロトニントランスポーター発現の変化"精神神経系薬物療法研究基金研究年報. 32(印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 鈴木一正,粟田主一 ほか: "緊張病症候群を呈する遅発性精神病の一例."精神医学. 43(印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shen H,Awata S, et al.: "ECS Regulates Serotonin Transporter mRNA Expression in Rat Raphe Nucleus."Psychiatry Clin.Neurosci.. 55(in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 島袋仁,粟田主一 ほか: "脳波上三相波を示したセロトニン症候群の一例"臨床精神医学. 30(印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 粟田主一: "Central Nervous System Today-3.感情障害、不安障害、睡眠障害、分裂病-基礎から臨床まで.(加藤進昌,樋口輝彦編)"難治性感情障害の治療におけるECT. 7-11 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Awata S.: "Vulnerability of late-life depression : As reviewed from the effect of electroconvulsive therapy on rCBF"Psyshiatr Clin Neurosci. 53. 86 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shen OHW,Awata S.et al.: "The effect of ECT on platelet ^3H-paroxetine binding in antidepressant-resistan severe depression"Psychiatr Clin Neurosci. 53. 110 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 鈴木一正、粟田主一,他: "m-ECT後に繰り返し再燃するうつ病に継続ECTと炭酸リチウムによる継続薬物療法が有効であった1例"精神科治療学. 15(印刷中). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 粟田主一,他: "電気けいれん療法後のうつ病の再燃脆弱性と局所脳血流動態の変化"精神薬療研究年報. 32(印刷中). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 粟田 主一、他: "Central Nervous System Today-3"(株)ライフ・サイエンス(印刷中). (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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