| Project/Area Number |
11670932
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | TOKYO MEDICAL AND DENTAL UNIVERSITY |
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Principal Investigator |
KURUMAJI Akeo TOKYO MEDICAL & DENTAL UNIVERSITY SCHOOL OF MEDICINE, LECTURER, 医学部・附属病院, 講師 (00251504)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Akiko TOKYO MEDICAL & DENTAL UNIVERSITY, GRADUATE SCHOOL, RESEARCH ASSISTANT, 大学院・医歯学総合研究科, 教務職員 (40210992)
YOSHIKAWA Takeo RIKEN, BRIN SCIENCE INSTITUTE TEAM LEADER, 脳科学総合研究所センター, チームリーダー (30249958)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | SCHIZOPHRENIA / NEUROTRANSMITTER / POLYMORPHISM / TYROSINE HYDROXYLAGE / ASSOCIATION / MISSENSE / BENZODIAZEPINE RECEPTORS(PERIPHERAL) / L1CAM / L1CAM / 遺伝子 / ミスセンス変異 / PCR |
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| Research Abstract |
An association study of missense mutations in the exon 4 of benzodiazepine receptors(peripheral)gene was performed in a Japanese sample of 304 schizophrenic patients and 369 controls. However, there were no statistically significant associations with schizophrenia in the polymorphisms. In addition, there were no associations between the polymorphisms and the affective disorders in a Japanese sample.
We found three polymorphisms in the human gene of L1CAM located in Xq28. An association study of the identified polymorphisms with schizophrenia was performed in a Japanese sample. A statistically significant increase in the count of the 13504 T-allele(7/152)was observed in the male patients, compared to the male controls(0/121). However, there were no changes in the frequencies of three mutations(allele or genotype)between the female patients and the female controls.
A polymorphic repeat of the tetranucleotide in the first intron of the TH gene was typed by a PCR-based process in a Japanese sample including schizophrenic patients and controls. There was a statistically significant association between the polymorphism and schizophrenia in females, but not in males. A genotype of heterozygous for the nine repeat and the six repeat was significantly decreased in female schizophrenics. These results suggest that TH could be considered as a minor gene contributing to the susceptibility of Japanese female schizophrenia.
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