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Behavioral and Histological Study in CCKBR Knockout Mouse

Research Project

Project/Area Number 11670951
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionOITA MEDICAL UNIVERSITY

Principal Investigator

AKIYOSHI Jotaru  Oita Med Univ, Associate Prof, 医学部, 助教授 (00159344)

Co-Investigator(Kenkyū-buntansha) TSUTSUMI Takashi  Oita Med Univ, Assistant Prof, 医学部, 助手 (60284791)
ISOGAWA Koichi  Oita Med Univ, Assistant Prof, 医学部, 助手 (10264334)
YAMAMOTO Yukiko  Oita Med Univ, Assistant Prof, 医学部, 助手 (50305041)
NAGAYAMA Haruo  Oita Med Univ, professor, 医学部, 教授 (70100899)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsAnxiety / Knockout Mouse / Cholecystokinin
Research Abstract

CCKBR mutant mice are hyposensitive to stress and display decreased anxiety-like behavior mutant mice have normal basal feeding and weight gain. CCK might be connected with anxiety.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Yamamoto Y, Akiyoshi J, et al.: "Increased anxiety behavior in OLETF rats without cholecystokinin-A receptor."Brain Research Bull. 53(6). 789-792 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hikichi T, Akiyoshi J, et al.: "Suppression of conditioned fear by administration of CRF/receptor antagonist CP-154,526"Pharmacopsychiatry. 33(5). 189-193 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Isogawa K, Akiyoshi J, et al.: "Effect of corticotropin releasing factor receptor I antagonist on extracellular norepirephrine, dopamine and serotonin in hippocampus and profrontal cortex of rats in vivo"Neuropeptides. 34(3/4). 234-292 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamamoto Y et al.: "Increased anxiety behavior in OLETF rats"Brain Res Bull. 53(6). 789-792 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hikichi T et al: "Suppression of conditioned fear by administration"Pharmacopsychiatry. 33(5). 189-193 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Isogawa K et al.: "Effect of corticotrpin releasing factor"Neuropeptide. 34(3/4). 234-292 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tsutsumi T.: "Suppression of conclitioned tear"Neuropeptides. 33. 483-486 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Katsuragi S: "Association between serotonin transporter"Biological Psychiatry. 45. 368-370 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Akiyoshi J: "Relation Ship between SCL-90,Maudsley"Psychiatry Research. 81. 381-386 (1998)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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