| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1999: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Research Abstract |
In patients with eating disorder, not only abnormal feeding behavior but abnormal general behaviors like hyper activity, impulsive behavior are observed. To clarify the biological basis of these behavior, rats with restricted scheduled feeding (SF-group), food deprivation (DP-group), and control (C-group) were observed their general behaviors including eating behavior, moving time, moving length, and number of rearing using a video image motion analysis system. The extracellular concentrations of DA, DOPAC, and HVA were also measured in rat striatum using microdialysis technique. Before free feeding when they moved to the monitor cage which mean new environment, moving time and length were increased in SF-group but it last less than 60 min. After free feeding began, rats ate more food in the order of SF-, DP- and C-group due to their feeding paradigms. On the other hand, any other general behaviors analyzed did not differ. The results suggested that the meal size were changed between the paradigms. DA metabolism in the SF-group was increased after free feeding compared with other groups. As other general behaviors were not changed, the difference in the DA metabolism might be due to feeding related factors. DA metabolism did not differed in DP- and C-group in spite of the different food intake. These results further suggested that the increased DA metabolism was not due to feeding behavior itself, but was due to feeding paradigms like stress reaction. Even in human eating disorders, not only the change of eating pattern but the stress reaction accompany with the chronic diet might related to their neurotransmitter abnormalities.
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