| Project/Area Number |
11670962
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka City University |
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Principal Investigator |
NAGATA Toshihiko Osaka City University Medical School, Dept. of Neuropsycilatry, Associate Professor, 大学院・医学研究科, 助教授 (80237528)
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| Co-Investigator(Kenkyū-buntansha) |
IKETANI Toshiya Osaka City University Medical School, Dept. of Neuropsychiatry, Lecturer, 大学院・医学研究科, 講師 (80295708)
飛谷 渉 大阪市立大学, 大学院・医学研究科, 助手 (90336769)
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| Project Period (FY) |
1999 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Bulimia Nervosa / Eating Disorders / Social Anxiety Disorder / Lymphocyte Prolilerative Response / Lymphocyte Subset / Stress / Lytokine / Psicho-Neuro-Immunology / social anxiety disorder / bulimia neruosa / lymphosyte subset / Lymphocyte proliferative response / immune function / eating disorders / bulimia nervoia / tumor necrosis factor / leukemia inhibition factor / Eating Disorders / bulimia nervosa / Psychoneuroimmunology / Lymphocyte subset / Lymphoproliferative response / psyohoneuroimmunology / Lymphocyte proliferative respose |
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| Research Abstract |
Subjects consisted of 20 female patients with bulimia nervosa (BN), 9 patients (6 were male) with social anxiety disorder (SAD) and 20 controls (6 were male). All were provided written informed consent. There were no significant differences in age or Body Mass Index among these groups. There were no significant differences in lymphocyte subsets such as CD4/CD8 ratio among these three groups. However, lymphocyte proliferative response with PHA/control ratio (Stimulation Index; SI) in BN patients was significantly lower than that in control women. SI was also significantly related with Beck's Depression Inventory score(r=-.56, p=.001), Trait subscale of State-Trait Anxiety Inventory (rs=-.58, p<.001), Emotion subscale of Coping Inventory for Stressful Situations (r=-.58, p<.001). In addition, lower SI in BN patients (N=9) significantly improved according to progress of treatment. SI in SAD patients were also significantly lower than that in C group (87±35 vs. 328±269, t=3.9, p=.001).
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