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The fundamental study of biofeedback treatments using biological markers such as Event-related potentials (ERPs) and exploratory eye movements (EEMs) in schizophrenic patients

Research Project

Project/Area Number 11670971
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKURUME UNIVERSITY

Principal Investigator

MORITA Kiichiro  KURUME UNIVERSITY, COGNITIVE AND MOLECULAR RESEARCH INSTITUTE OF BRAIN DISEASES, ASSOCIATE PROFESSOR, 高次脳疾患研究所, 助教授 (20140642)

Co-Investigator(Kenkyū-buntansha) SHOJI Sumio  KURUME UNIVERSITY, MEDICINE, ASSISTANT PROFESSOR, 医学部, 助手 (50343695)
MAEDA Hisao  KURUME UNIVERSITY, MEDICINE, PROFESSOR, 医学部, 教授 (60089919)
森田 恵史  久留米大学, 医学部, 助手 (30322598)
宮平 綾子  久留米大学, 医学部, 助手 (30291826)
山口 浩  久留米大学, 医学部, 助手 (50299509)
Project Period (FY) 1999 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2002: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2001: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsschizophrenic / recover period / event-related potentials / exploratory eye movements / emotional stimuli / biological markers / biofeedback treatments / emotional cues / 統合失調症 / 回復・寛解過程 / 視覚誘発事象関連電位 / バイオフィードバック / 精神分裂病 / 聴覚誘発事象関連電位
Research Abstract

In schizophrenic patients, event-related potentials (ERPs) and exploratory eye movements (EEMs) have been used as biological correlates of information processing. Previously, Morita, tile prinspal investigator in this study, investigated ERPs and EEMs during recover period in schizophrenic patients in comparison with these in healthy subjects. This study and compared the effects of facial affective stimuli on visual ERPs and EEMs using photographs of babies crying and smiling while recording autonomic vital markers such as ECG, skin conductance and heart rate to monitor the emotional responses. We reported that the P300 amplitude, area and eye movements became more similar to those of healthy subjects after recovery from illness. For example, the P300 amplitude and area while viewing photograph of a smiling baby were the same as these while viewing crying baby. However, the values while viewing smiling baby were smaller than these while viewing crying baby at clinical improving phase in the patients. These findings suggest that both the ERPs and EEMs evoked by these facial affect stimuli are useful biological state markers and may be useful as feed back during clinical treatment. However, the findings were insufficient to record the emotional effects reflected by ECG, skin conductance and heart rate during ERPs and EEMs recordings. Thus, we are currently trying to monitor the ERPs, EEMs and other markers using crying and laughing voices and pleasant and unpleasant odors. These additional stimuli caused larger emotional effects and changed several biological markers. The degree of emotional level induced by facial-affect recognition with voices and odors may vary more depending on the clinical state. The failure to accurately read nonverbal emotional cues may contribute to inappropriate social responses.

Report

(5 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Nakayama H, et al.: "Improvement of exploratory eye movements in schizophrenic patients during recovery period"Psychiatry Clin Neurosci. 57. 169-176 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 森田喜一郎等: "精神分裂病者と健常者の事象関連電位-赤ちゃん表情の影響"臨床脳波. 44. 154-159 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 森田喜一郎等: "精神分裂病者と健常者の探索眼球運動-赤ちゃん表情の影響"臨床脳波. 44. 154-159 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Morita Y, et al.: "Effects of facial affect recognition on the auditory P300 in healthy subjects"Neuroscience Research. 104. 89-95 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ryu H et al.: "Abnormal exploratory eye movements In schizophremc patents vs healthy subjects"Acta Neurol Scand. 104. 369-376 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 上野雄文 等: "精神分裂病者の探索眼球運動における情動の影響:健常者との比較検討"臨床神経生理学. 30. 60-66 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakayama H, et al.: "Improvement of exploratory eye movements in schizophrenic patients during recovery period"Psychiatry Clin Neurosci. 57. 169-176 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Morita Y, et al.: "Effects of facial affect recognition on the auditory P300 in healthy subjects"Neuroscience Research. 104. 89-95 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ryu H et al.: "Abnormal exploratory eye movements In schizophrenic patients vs healthy subjects"Acta Neurol Scand. 104. 369-376 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 森田喜一郎 等: "精神分裂病者と健常者の探索眼球運動-赤ちゃん表情の影響-"臨床脳波. 44. 154-159 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Morita Y, et al.: "Effects of facial affect recognition on the auditory P300 in healthy subjects"Neuroscience Research. 104. 89-95 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ryu H et al.: "Abnormal exploratory eye movements In schizophrenic patients vs healthy subjects"Acta Neurol Scand. 104. 369-376 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 上野雄文 等: "精神分裂病者の探索眼球運動における情動の影響:健常者との比較検討"臨床神経生理学. 30. 60-66 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 森田喜一郎 等: "末服薬統合失調症者と健常者の視覚誘発事象関連電位(P300成分)-情動の影響をふまえて"臨床脳波. 46. 76-82 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 森田喜一郎 等: "探索眼球運動を用いた統合失調症者における正円図の反復刺激の影響"精神医学. 45. 303-309 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 森田喜一郎 等: "精神分裂病者と健常者の探索眼球運動-赤ちやん表情の影響"臨床脳波. 44. 154-159 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Morita Y, et al.: "Effects of facial affect recognition on the auditory P300 in healthy subjects"Neuroscience Research. 104. 89-95 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ryu H et al.: "Abnormal exploratory eye movements In schizophrenic patients vs healthy"Acta Neurol Scand. 104. 369-376 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 上野雄文 等: "精神分裂病者の探索眼球運動における情動の影響:健常者との比較検討"臨床神経生理学. 30. 60-66 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 森田喜一郎 等: "老年期分裂病者の探索眼球運動における特徴晩期寛解について"臨床脳波. 43. (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamamoto M et al.: "Changes in auditory P3000with clinical remission in schizophrenia ; Effects of facial-affect stimuli."Psychiatry and Clinical Neuroscience. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 前田久雄、森田喜一郎等: "聴覚P300成分に対する表情認知の影響"臨床脳波. 41. 565-570 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 山本正史、森田喜一郎等: "精神分裂病の寛解過程において多面的評価を試みた1症例"九州神経精神医学. 45. 153-158 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 森田喜一郎等: "健常者の聴覚事象関連電位に対する表情認知の影響"臨床脳波. 42. 7-11 (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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