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Association of human herpesvirus 6 (HHV-6) in hematological malignancies and vertical transmission of HHV-6 genome

Research Project

Project/Area Number 11671002
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionKochi Medical School

Principal Investigator

DAIBATA Masanori  Faculty of Medicine, Kochi Medical School, Assistant Professor, 医学部・附属病院, 講師 (50263976)

Co-Investigator(Kenkyū-buntansha) TAGUCHI Takahiro  Faculty of Medicine, Kochi Medical School, Instructor, 医学部, 助手 (80127943)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsEpstein-Barr virus / human herpesvirus 6 / human herpesvirus 7 / human herpesvirus 8 / hematological malignancies / virus reactivation / vertical transmission / Epstein-Barrウイルス / ヒトへルペスウイルス8
Research Abstract

1. Over the past 15 years three new human hepesviruses (HHV-6, HHV-7 and HHV-8) have been recognized and implicated as eliological agents of several human diseases. HHV-6 has been cited as a possible cause or as a modulating element of certain human lymphoproliferative disorders. We found two cases of lymphoma and ALL carrying chromosomally integrated HHV-6 genomes. To assess the possibility of chromosomal transmission of HHV-6 DNA, we looked for the viral genome in their families. In both cases, the HHV-6 genomes were detected in their offspring at the identical sites of viral integration of the patients. We propose a novel latent form for HHV-6, in which integrated HHV-6 genome can be chromosomally inherited.
2.(1) Despite the genomic homology, and serological cross-reactivity between HHV-6 and HHV-7, evidence for the association of HHV-7 with lymphoproliferative disorders has been scarce. We searched for the HHV-7 genome in patients with lymphocytic leukemia. Sixty-one patients were enrolled : 33 adult ALL ; 15 childhood ALL ; and 13 CLL. HHV-7 genome was not found in any of our samples, suggesting that HHV-7 is unlikely to play a pathogenetic role in lymphocytic leukemia.
(2) We evaluated the presence of four human herpesviruses (EBV, HHV-6, HHV-7 and HHV-8) in the specimens from 14 patients with primary ocular MALT lymphoma. EBV DNA were detected in 4 samples by PCR, and 4 cases were positive for HHV-6DNA. Neither HHV-7 nor HHV-8DNA could by detected. These findings suggested the possible involvement of EBV and HHV-6 in the pathogenesis of a subset of low-grade primary ocular lymphomas.
(3) HHV-6 genome was detected in the brain lesions of progressive multifocal leukoencephalopathy (PML) developing in a lymphoma patient. HHV-6 is known to be reactivated during immunosuppression and can cause several fatal complications. We propose an association of HHV-6 with the pathogenesis of PML in immunocompromised hosts.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] Masanori Daibata: "Inheritance of chromosomally integrated human herpesvirus 6 DNA"Blood. 94. 1545-1549 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masanori Daibata: "Presence of human herpesvirus 6 DNA in cord blood cells"J. Infect. Dis.. 179. 1046 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masanori Daibata: "Integration of human herpesvirus 6 DNA in lymphoproliferative disorders and its transmission"Recent Research Developments in Virology. 1. 1-6 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masanori Daibata: "Human herpesvirus 7 and lymphocytic leukaemia"Br. J. Haematol.. 104. 934 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masanori Daibata: "Human herpesviruses in primary ocular lymphoma"Leukemia and Lymphoma. 37. 361-365 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hiroya Asou: "Co-infection of HHV-6 and HHV-8 is rare in primary effusion lymphoma"Leukemia Research. 24. 59-61 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masanori Daibata: "Constitutional t(3;11)(p21;q23) in a family, including one member with malignant lymphoma : Establishment of novel cell lines with this translocation"Cancer Genet. Cytogenet.. 117. 28-31 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masanori Daibata: "Presence of human herpesvirus 6 DNA in somatic cells"Blood. 95. 1108-1109 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nobuo Hatakeyama: "Lactate dehydrogenase production and release in a newly established human myeloma cell line"Am. J. Hematol.. 66. 267-273 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masanori Daibata: "Detection of human herpesvirus 6 and JC virus in progressive multifocal leukoencephalopathy complicating follicular lymphoma"Am. J. Hematol.. 67. 200-205 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 大畑 雅典: "ヒトヘルペスウイルス6および8と悪性リンパ腫"日本臨床. 58. 46-52 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 大畑 雅典: "リンパ指向性ウイルスと造血器腫瘍"血液・腫瘍科. 118. 181-188 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 大畑 雅典: "EBV、HHV-6と造血器疾患"臨床血液. 42. 464-467 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masanori Daibata: "Inhertance of chromosomally integrated human herpesvirus 6 DNA"Blood. 94. 1545-1549 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masanori Daibata: "Presence of human herpesvirus 6 DNA in cord blood cells"J. Infect. Dis.. 179. 1046 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masanori Daibata: "Integration of human herpesvirus 6 DNA in lymphoproliferative disorders and its transmission"Recent Research Developments in Virology. 1. 1-6 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masanori Daibata: "Human herpesvirus 7 and lymphocytic leukaemia"Br. J. Haematol.. 104. 934 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masanori Daibata: "Human herpesviruses in primary ocular lymphoma"Leukemia and Lymphoma. 37. 361-365 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hiroya Asou: "Co-infection of HHV-6 and HHV-8 is rare in primary effusion lymphoma"Leukemia Research. 24. 59-61 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masanori Daibata: "Constitutional t(3 ; 11)(p21 ; q23) in a family, including one member with malignant lymphoma : Establishment of novel cell lines with this translocation"Cancer Genet. Cytogenet.. 117. 28-31 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masanori Daibata: "Presence of human herpesvirus 6 DNA in somatic cells"Blood. 95. 1108-1109 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nobuo Hatakeyama: "Lactate dehydrogenase production and release in a newly established human myeloma cell line"Am. J. Hematol.. 66. 267-273 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masanori Daibata: "Detection of human herpesvirus 6 and JC virus in progressive multifocal leukoencephalopathy complicating follicular lymphoma"Am. J. Hematol.. 67. 200-205 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Daibata: "Detection of human herpevirus 6 and JC virus in progressive multifocal leukoencephalopathy complicating follicular lymphoma"Am.J.Hematol.. 67. 200-205 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] N.Hatakeyama: "Lactate dehydrogenase production and release in a newly established human myeloma cell line"Am.J.Hematol.. 66. 267-273 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] A.Hayakawa: "Genomic organization, tissue expression, and cellular localization of AF3p21, a fusion partner of MLL in therapy-related leukemia"Genes Chrom.Cancer. 30. 364-374 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Daibata: "Presence of human herpesvirus 6 DNA in somatic cells."Blood. 95. 1108-1109 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Asou: "Co-infection of HHV-6 and HHV-8 is rare in primary effusion lymphoma"Leukemia Res. 24. 59-61 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.Daibata: "Human herpesviruses in primary ocular lymphoma."Leukemia and Lymphoma. 37. 361-365 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大畑雅典: "ヒトヘルペスウイルス6および8と悪性リンパ腫"日本臨床. 58(3). 46-52 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大畑雅典: "リンパ指向性ウイルスと造血器腫瘍"血液・腫瘍科. 41(2). 181-188 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Masanori Daibata: "Presence of human herpesvirus 6 DNA in cord blood cells."J Infect Dis. 179. 1046-1047 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Masanori Daibata: "Human herpesvirus 7 and lymphocytic leukaemia."Br J Haematol. 104. 934 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Masanori Daibata: "Inheritance of chromosomally integrated human herpesvirus 6 DNA."Blood. 94. 1545-1549 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Masanori Daibata: "Constitutional t(3;11)(p21;q23) in a family,including one member with maliquant lymphoma:Establishment of novel cell lines with this translocation."Cancer Genet Cytogenet. 117. 28-31 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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