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The role of androgen for the production of pulsatile secretion of growth hormone.

Research Project

Project/Area Number 11671100
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionInstitute of Gerontology, Nippon Medical School

Principal Investigator

MINAMI Shiro  Nippon Medical School Institute of Gerontology Professor, 老人病研究所, 教授 (10192361)

Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2000: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥2,500,000 (Direct Cost: ¥2,500,000)
Keywordsgrowth hormone / ultradian rhythm / androgen / somatostatin / hypothalamus / c-fos / フィードバック調節 / ニューロペプチドY
Research Abstract

There is a striking sex difference in the pattern of growth hormone (GH) secretion in rats. It has been shown that 2 weeks treatment with dihydrotestosterone (DHT) produces male-like secretory pattern of GH in ovariectomized (OVX) female rats. To elucidate the mechanism by which androgen masculinize GH secretory pattern, we have examined the acute effects of androgen on changes of the secretory pattern of GH, and then, the primary site of action of androgen.
(1) The subcutaneous administration of 0.01-1.0 mg of DHT produced male-like pattern of GH secretion in OVX rats within 6-12 h, but not in normal female rats. (2) DHT did not produce any changes of GH secretion in OVX rats with the anterolateral deafferentation of the medial basal hypothalamus which disrupted the interaction between the anterolateral area of the hypothalamus and the medial basal hypothalamus. (3) DHT, 1 μg, was microinjected directly into the restricted areas of the brain of the OVX rats to determine the primary site of action of DHT to masculinize GH secretion. DHT injection into the medial preoptic nucleus (MPO) or its vicinity effectively changed the GH secretion to male pattern, whereas the injection into the other areas was not effective. (4) The intravenous administration of DHT induced c-fos mRNA in most of the areas known to be positive for androgen receptor, including the MPO.
It is concluded that the MPO is the site where androgen acts to produce male-like secretory pattern of GH, and that estrogen in intact female rats prevents the masculinizing effect of androgen.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Shiro Minami: "Cellular localization of prolactin-releasing peptide messenger RNA in the rat brain."Neuroscience Letters. 266. 73-75 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hitoshi Sugihara: "Effect of insulin-like growth factor-I on growth hormone-releasing factor receptor expression in primary rat anterior pituitary cell culture."Neuroscience Letters. 276. 87-90 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takashi Yokota: "Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma."Journal of Juman Genetics. 45. 6-11 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Reiko Tokita: "Prolactin becretion in response to PrRP and the expression of the PrRP gene in the medulla oblongata are estrogen dependent."Neuroscience Letters. 276. 103-106 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hideki Tamura: "Masculinizing effect of DHT on GH secretion is inhibited in ovariectomized rats with anterolateral deafferentation of the medial basal hypothalamus or in intact femal rats."Journal of Neuroendocrinology. 12. 369-375 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Naoko Chikada: "Distribution of C-fos mRNA in the brain following icv injectior of NO-releasing compounds : possible role of NO in central cardiovascular regulation."Journal of Neuroendocrinology. 12. 1112-1123 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Minami S., et al.: "Celuular localization of prolactin-releasing peptide messenger RNA in the rat brain."Neuroscience Letters. 266. 73-75 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sugihara H., et al.: "Effect of IGF-I on GH-releasing factor receptor expression in primary rat anterior pituitary cell culture."Neuroscience Letters. 276. 87-90 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yokota T., et al.: "Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma."Journal of Human Genetics. 45. 6-11 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tokita R., et al.: "Prolactin secretion in response to PrRP and the expression of the PrRP gene in the medulla oblongata are estrogen dependent."Neuroscience Letters. 276. 103-106 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tamura H.et al.: "Masculinizing effect of DHT on GH secretion is inhibited in ovariectomized rats with anterolateral deafferentation of the medial basal hypothalamus or in intact female rats."Journal of Neuroendocrinology. 12. 369-375 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Chikada N., et al.: "Distribution of c-fos mRNA in the brain following icv injection of NO-releasing compounds : possible role of NO in central cardiovasculkr regulation."Journal of Neuroendocrinology. 12. 1112-1123 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shiro Minami: "Cellular localization of prolactin-releasing peptide messenger RNA in the rat brain."Neuroscience Letters. 266. 73-75 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hitoshi Sugihara: "Effect of insulin-like growth factor-I on growth hormone-releasing factor receptor expression in primary rat anterior pituitary cell culture."Neuroscience Letters. 276. 87-90 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takashi Yokota: "Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma."Journal of uman Genetics. 45. 6-11 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Reiko Tokita: "Prolactin secretion in response to PrRP and the expression of the PrRP gene in the medulla oblongata are estrogen"Neuroscience Letters. 276. 102-106 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hideki Tamura: "Masculinizing effect of DHT on GH secretion is inhibited in ovariectomized rats with anterolateral deafferentation of the medial basal hypothalamus or in intact female rats."Journal of Neuroendocrinology. 12. 369-375 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Naoko Chikada: "Distribution of c-fos mRNA in the brain following icv injecti of NO-releasing compounds : possible role of NO in central cardiovascular regulation."Journal of Neuroendocrinology. 12. 1112-1123 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shiro Minami: "Cellular localization of prolactin -releasing peptide messenger RNA in the rat brain"Neurosciencr Letters. 266. 73-75 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Marumi Katsumata: "Familial hypercholesterolemia Utah kindred with novel R103W mutation in Exon 4 of the LDL receptor gene"Japanese Heart Journal. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Reiko Tokita: "Prolactin secretion in response to prolactin-releasing peptide(PrRP)and the expression of the PrRP gene in the medulla oblongata are estrogen dependent in rats"Neuroscience Letters. 276. 103-105 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takashi Yokota: "Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carsinoma"Journal of Human Genetics. 45. 6-11 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hitoshi sugihara: "Effect of insulin-like growth factor-I on growth hormone-releasing factor receptor expression in primary rat anterior pituitary cell culture"Neuroscience Letters. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Hideki Tamura: "Masculinizing effect of dihydrotestosterone on growth hormone secretion is inhibited in ovariectomized rats with anterolateral deafferentation of the medial basal hypothalamus"Journal of Neuroendocrinology. (in press).

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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