Search for susceptible genes to diabetes mellitus in Japanese.

• Project/Area Number: 11671105
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Okinaka Memorial Institute for Medical Research (2000-2001); University of Tsukuba (1999)
• Principal Investigator: ODAWARA Masato Okinaka Memorial Institute for Medical Research, 研究員 (00224254)
• Project Period (FY): 1999 – 2001
• Project Status: Completed (Fiscal Year 2001)
• Budget Amount: ¥3,600,000 (Direct Cost: ¥3,600,000); Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000); Fiscal Year 2000: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 1999: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: diabetes mellitus / genomic DNA / caudidate gene / polymosphi / inshulin secretion / inshulin resistance / インスリン抵抗性 / 遺伝子 / 多型 / 変異 / 日本人 / ミトコンドリア

Research Abstract

The number of patients afflicted with type 2 diabetes has risen sharply in Japan these ten to twenty years, at least partly because of a westernization of eating habit and of a sedentary life style. Previously, it was thought that genes involved in the pathogenesis of impaired insulin secretion are more important than those involved in the development of insulin resistance in Japanese. Recent observations, however, suggest that those genes responsible for the development of insulin resistance or obesity are as important. We extracted genomic DNA from unrelated Japanese patients with type 2 diabetes mellitus. We investigated for an association of polymorphisms, which have been reported to be present near candidate genes for the development of type 2 diabetes mellitus. We also investigated for a possible association of those genetic variants, identified by us, with type 2 diabetes mellitus in Japanese. We could not find a significant association of the genetic variants, with type 2 diabetes mellitus. Increased number of DNA samples seems to be necessary to identify susceptible genes for the development of diabetes mellitus.

Research Products

• [Publications] Odawara M., et al.: "Cerebral hypo-accumulation in SPECT in a maternally intented diabetes with deafness patient."J.Stroke and Cerebrovascular Disease. 1. 291-292 (2000)
• [Publications] Ozawa S,Ozawa T,Odawara M.: "A new role of upper gastrointestinal endoscopy."Ann Int Med. 132(6). 510-510 (2000)
• [Publications] Odawara et al.: "Endothelial nitric oxide synthase gene polymorphism and coronary heart disease in Japanese NIDDM"Diabetologia. 41(3). 365-366 (1998)
• [Publications] Odawara et al.: "A common mutation of the methylenetetrahydrofolate reductase gene as a risk factor for diabetic nephropathy"Diabetologia. 42. 631-632 (1999)
• [Publications] Odawara et al.: "Pathogenicity of homoplasmic mitochondrial DNA mutation and nuclear gene involvement"J Med Genetics. 36(12). 934-935 (1999)