| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥3,000,000 (Direct Cost: ¥3,000,000)
|
|---|
| Research Abstract |
Insulin-dependent diabetes mellitus (IDDM) is a multi-factorial disease caused by an environmental factor and genetic factors. Once affected with IDDM, patients can hardly attain good glycaemic control and suffers from chronic diabetic complication. To establish predicting methods and preventing methods, we performed genetic analysis of IDDM using diabetic patients and control subjects. In the analysis of the HLA gene region, where the strongest disease-susceptibility gene (IDDM1) is located, we found an association between the polymorphism of MHC class I chain-related gene A (MICA), a gene involved with immune reaction, and age-at-onset of IDDM, thereby indicatting that MICA may contribute to the heterogeneitv of clinical characteristice of IDDM.In respect of non-MHC genes, we analysed genes on chromosome 2. So far three susceptibility genes (IDDM7, IDDM12, IDDM13) were marted on chromosome 2. We analysed there three genes using the same sample set and found that contribution of IDDM13 is strongest among these genes in Japanese. We further analysed the IA-2 genes, the candidate gene located near IDDM13. We found no association between the polymorphism of the IA-2 gene and IDDM, which suggest that the gene does not contribute to the susceptibility of IDDM.
|
