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Prevalence and Significance of Anti-CD38 Autoantibody Detected in Patients with Type 2 Diabetes.

Research Project

Project/Area Number 11671121
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionKagawa Medical University

Principal Investigator

TAMINATO Tomohiko  Kagawa Medical University, Dept. of Laboratory Medicine, Professor, 医学部, 教授 (90107954)

Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsCD38 / AntiCD38 antibody / Diabetes mellitus / Insulin secretion / ADP-ribosyl cyclase / Cyclic ADP-ribose
Research Abstract

The present study attempted to clarify the prevalence and significance of anti-CD38 antibody, which can be detected in sera from diabetic patients. Sera were collected from 184 type 2 diabetics. An ElA system was developed to detect anti-CD38 antibody using Keyhole Limpet Hemocyanin (KLH) -conjugated CD38 fragment peptides, 287-297 (N-CVKNPEDSSCT-C (Ag-1) and 241-255 (N-CSNNPVSVFWKTVSR-C (Ag-2), as antigens.
Among 184 diabetics, anti-CD38 antibody was detected in 43 patients. Most of antibody positive sera reacted with Ag-1 and a part of those reacted with Ag-2. The clinical characteristics of antibody-positive patients were short-duration of diabetes, higher blood glucose level, less white blood cell counts, and receiving diet or oral hypoglycemic agents, rather than insulin. Antibody-positive patients were shown to have relatively higher level of serum and urinary C-peptide than type 1 diabetics, suggesting modest potential reservation of insulin secretion. Anti-CD38 antibody was not concordant with anti-GAD or anti-microsomal antibodies in those patients. Pretreatment of partially purified lgG from the antibody positive sera inhibited D-glucose-induced insulin release from isolated rat islets.
These results suggest that anti-CD38 antibody has a significant diagnostic and prognostic values in the diagnosis of worsening of type 2 diabetes or progression to type 1 diabetes.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Rydzewski A,: "Diurnal variation in serum remnant-like lipoproteins, platelet aggregation and fibrinolysis in healthy volunteers"Haemostasis. 27. 305-14 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ikegaya N,: "Impairment of ventilatory response to metabolic acidosis in insulin-dependent diabetic patients with advanced nephropathy."Ren Fail.. 21(5). 495-8 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 田港朝彦,: "糖尿病2.日本臨床社刊"CD38(ADP-ribosyl cyclase)とインスリン分泌。. 7 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Taminato T, Ito T, Kato H.: "CD38 antigen (ADP-ribosyl cyclase) and Secretory mechanism of insulin secretion. (in Japanese)"Nippon Rinsho. 55 (suppl). 880-87 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Rydzewski A, Urano T, Nagai N, Takada Y, Kato-Ohishi H, Taminato T, Yoshimi T, Takada A.: "Diurnal variation in serum remnant-like lipoproteins, platelet aggregation and fibrinolysis in healthy volunteers"Haemostasis. 27. 305-14 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ikegaya N, Yonemura K, Suzuki T, Kato-Ohishi H, Taminato T, Hishida A.: "Impairment of ventilatory response to metabolic acidosis in insulin-dependent diabetic patients with advanced nephropathy."Ren Fail.. 21 (5). 495-8 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Taminato, T.Ito, H.Kato-Ohishi, H.Mizawa, A.Miyagawa and J.Miyazaki.: "Inhibition of Glucose-Induced Insulin Release and Intracellula Ca2+Response by Anti-CD38 Antibody"(submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Taminato, H.Mizawa, T.Ito, H.Kato-Ohishi: "Prevalence and Significance of Anti-CD38 Autoantibody Detected in Patients with Type 2 Diabetes."(submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ikegaya N,Yonemura K,Suzuki T,Kato-Ohishi H,Taminato T,Hishida A.: "Impairment of ventilatory response to metabolic acidosis in insulin-dependent diabetic patients with advanced nephropathy."Ren Fail.. 21(5). 495-498 (1999)

    • Related Report
      2000 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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