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The inhibitory effect of Leptin on the unresponsiveness to glucose induced by high glucose consentrat ion in isolated islets form rats

Research Project

Project/Area Number 11671139
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionYokohama City University College of Nursing

Principal Investigator

EGAWA Masato  Yokohama City University College of Nursing, Dept. of Physiopathology, Proffer, 病態学, 教授 (40232938)

Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsleptin / islets / Glucose / glucose toxieity / Rats / mice / マウス / ランゲルハンス氏島
Research Abstract

It is reported that Leptin has the opening action in ATP dependence K + channel of pancreatic beta cell (Diabetes.46 : 1087(1997).). Since Diazoxide the opener of ATP dependence K + channel, suppresses "the sugar unresponsiveness induced by hyperglyceraia", we examined the possibility that the endogenic leptin also suppress the unresponsiveness induced by hyperglyceraia in islets isolated from rats and mice.

Report

(3 results)
  • 2001 Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 江川正人: "高ブドウ糖濃度によるラット単離膵島の糖不応性に対するleptinの抑制作用"糖尿病. 42. S242 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masato Egawa: "The inhibitory effect of Leptin on the unresponsiveness to glucose induced by high glucose consentration"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto M,Shimura S,Itoh Y,Ohsaka T,Egawa M,Inoue S.: "Anti-obesity effects of lipase inhibitor CT-II, an extract from edible herbs, Nomame Herba, on rats fed A high-fat diet."Int J Obes Relat Metab Disord. 24・6. 758-764 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 佐藤忍,宇高直子,江川正人 他: "膵β細胞インスリン分泌調節におけるIRS-1の役割"糖尿病. 43・Suppl.1. 264 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Satoh S,Udakaa N,Ito T,Egawa M etc: "Role of Insulin Receptor Substrate-1 in Islet Function"Diabetes. 49・Suppl.1. A255 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 江川正人: "高ブドウ糖濃度によるラット単離膵島の糖不応性に対するleptinの抑制作用"糖尿病. 42. S242 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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