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DRUG SENSITIVITIES FOR CANCER CHEMOTHERAPHY OR LIVER DYSFUNCTION AFTER OPERATION DEPENDING ON THE GENETIC POLYMORPHISMS OF DRUG METABOLIC ENZYMES

Research Project

Project/Area Number 11671192
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionNIPPON MEDICAL SCHOOL

Principal Investigator

KATO Shunji  NIPPON MEDICAL SHCOOL FIRST DEPT.OF SURGERY ASSISTANT PROFESSOR, 医学部, 助手 (60224507)

Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1999: ¥900,000 (Direct Cost: ¥900,000)
KeywordsGLUTAHTION S-TRANSFERASE / CYTOCHROME P450 2E1 / GENETIC POLYMORPHISM / LIVER DYSFUNCTION AFTER SURGERY / METABOLIC ENZYMES / SENSITIVITY FOR CHEMOTHERAPY / グルタチオン-S-トタンスフェラーゼ / GSTM1遺伝子 / チトクロームP450 2E1 / 胃癌
Research Abstract

Research results are summarized as following :
(1) Clinical study for the prediction of liver dysfunction after surgery : The influences of the surgical stress and inter-individual variations of the metabolic enzyme activity.
Surgical stress due to the differences of operation procedures was the important factors for the liver dysfunction after operation, and Glutathione S-Transferase M1 gene deletion might be a individual risk factor as inter-individual variations of host factors.
(2) Modulation of the intratumoral Dihydropyrimidine Dehydrogenase (DPD) and Thymidylate Synthase (TS) mRNA levels and Cytochrome p450 2E1 genetic polymorphisms for chemotherapy sensitivities in Stomach Cancer.
Cytochrome p4502E1 genetic polymorphism may associated with the sensitivity for 5FU based chemotherapy and the measurements of TS or DPD mRNA levels may predict the efficacy of 5-FU based therapy and may also predict the severe adverse reaction with the deficiency or low level of DPD enzyme in individuals.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] 加藤俊二 他: "胃癌手術後の肝障害発生要因の解析"日本外科系連合学会雑誌. 24. 580-585 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 加藤俊二 他: "広範囲血液・尿化学検査,免疫学的検査(1)-その数値をどう読むか-グルタチオンS-トランスフェラーゼ"日本臨牀. 57. 451-453 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 加藤俊二 他: "胃切除後の骨代謝障害とその評価:Microdensitometry(MD)法およびMD/MS (Multiple scanning X-ray photodensitometry)法による骨量測定"日本外科系連合学会雑誌. 25. 36-42 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 加藤俊二 他: "術後肝障害発生要因の解析とプロスペクティブスタディによる肝障害発症の予防"日本外科系連合学会雑誌. 25. 166-172 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 松倉則夫,加藤俊二 他: "Helicobacter pylori除菌による高位胃癌発生リスク"消化器内視鏡. 12. 431-434 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 加藤俊二 他: "肝硬変の発癌を促進するアルコールの影響"消化器科. 31. 50-55 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 松倉則夫,加藤俊二 他: "H.pylori除菌治療による腸上皮化生の可逆性の検討"Therapeutic Research. 21. 2548-2550 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 加藤俊二 他: "後腹膜転移巣の病理診断にて原発巣を診断し得た前立腺癌の1例"日本外科系連合学会雑誌. 26. 110-114 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 松田範子,加藤俊二 他: "C型肝炎抗体陽性者におけるAcetaldehyde dehydrogenase (ALDH2)酵素の遺伝的個体差と肝癌発生との関連"日本肝臓学会雑誌. 42(in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sirikan Y.,Kato S, et al: "Genetic Differences in CYP2C19 Single Nucleotide Polymorphisms among Four Asian Nationalities."J Gastroenterology. 36(in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kato S., et al: "The association of the interleukin-1 β genetic polymorphism and gastric cancer risk in Japanese"J Gastroenterology. 36(in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shunji Kato, et al: "Clinical factors inducing liver dysfunction after stomach surgery"Journal of Japanese College of Surgeons. 24. 580-585 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shunji Kato, et al: "Glutathione S-transferase"NIHON RINSHO. 57. 451-453 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shunji Kato, et al: "The symptoms of osteoporosis after gastrectomy and the evaluation of bone density by microdensitometry (MD) and MD/MS (multiple scanning X-ray photodensitometry) method"Journal of Japanese College of Surgeons. 25. 36-42 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shunji Kato, et al: "Clinical factors inducing liver dysfunction after stomach surgery and its prevention analyzed by prospective study"Journal of Japanese College of Surgeons. 25. 166-172 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Norio Matsukura, Shunji Kato, et al: "Cardia stomach cancer risk and Helicobacter pylori eradication"Gastrointestinal Endoscopy. 12. 431-434 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shunji Kato, et al: "Alcohol metabolic enzymes and liver carcinogenesis"Gastroenterology. 31. 50-55 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Norio Matsukura, Shunji Kato, et al: "Eradication of a Helicobacter pylori and the reversibility of intestinal metaplasia in the stomach"Therapeutic Research. 21. 2548-2550 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shunji Kato, et al: "Metastatic Prostate Cancer in Retroperitoneal Tumors Diagnosed by the Pathological Examination as an Occult Carcinoma"Journal of Japanese College of Surgeons. 26. 110-114 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sirikan Yamada., Shunji Kato, et al: "Genetic Differences in CYP2C19 Single Nucleotide Polymorphisms among Four Asian Nationalities"J Gastroenterology. 36 (impress). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shunji Kato et al: "The association of the interleukin-1 β genetic polymorphism and gastric cancer risk in Japanese"J Gastroenterology. 36 (impress). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 加藤俊二 他: "胃癌手術後の肝障害発生要因の解析"日本外科系連合学会雑誌. 24. 580-585 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 加藤俊二 他: "広範囲 血液・尿化学検査,免疫学的検査(1)-その数値をどう読むか-グルタチオンS-トランスフェラーゼ"日本臨床. 57. 451-453 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 加藤俊二 他: "胃切除後の骨代謝障害とその評価:Microdensitometry(MD)法およびMD/MS(Multiple scanning X ray photodensitometry)法による骨量測定"日本外科系連合学会雑誌. 25. 36-42 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 加藤俊二 他: "術後肝障害発生要因の解析とプロスペクティブスタディによる肝障害発症の予防"日本外科系連合学会雑誌. 25. 166-172 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 松倉則夫,加藤俊二 他: "Helicobacter pyloi除菌による高位胃癌発生リスク"消化器内視鏡. 12. 431-434 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 加藤俊二 他: "肝硬変の発癌を促進するアルコールの影響"消化器科. 31. 50-55 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 加藤俊二 他: "胃癌手術後の肝障害発生要因の解析"日本外科系連合学会雑誌. 24. 580-585 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 加藤俊二 他: "広範囲、血液、尿化学検査、免疫学的検査(1)グルタチオン-S-トランスフェラーゼ"日本臨牀. 57. 451-453 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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