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Basic and clinical analysis of basic FGF in the regenerating liver

Research Project

Project/Area Number 11671245
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionEhime University

Principal Investigator

FUMIKI Kushihata  Ehime university, Faculty Medicine University Hospital Instructor, 医学部・附属病院, 助手 (70284396)

Co-Investigator(Kenkyū-buntansha) MATSUDA Seiji  Ehime university, Department of 1st. Anatomy, Professor, 医学部, 教授 (40173843)
KOBAYASHI Nobuaki  Ehime university, Department of Surgery, Professor, 医学部, 教授 (60135564)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1999: ¥2,800,000 (Direct Cost: ¥2,800,000)
Keywordsbasic fibroblast growth factor (bFGF) / regenerating liver / cytokine / FGF receptor / hepatectomy / SIRS(systemic inflammatory response syndrome) / 蛋白分解酵素阻害剤 / bFGF / 肝再生
Research Abstract

This project was performed to investigate the localization and its inhibitory factor of bFGF binding sites in regenerating rat liver, and the changes of inflammatory and antiinflammatory cytokines during hepatectomy. Immunoblot experiments showed a transient increase of bFGF receptor in the nuclear subcellular fraction of regenerating liver and 125 I-bFGF binding assay indicated specific bFGF binding sites in nuclei and binding capacity increased in regenerating liver than that of control rats.
Both Inflammatory cytokines such as IL6, TNF α and antiinflammatory cytokine such as IL10 were increased during operation. No definite changes of serum bFGF was detected during hepatectomy.
These results suggest an important role of bFGF and inflammatory cytokines in hepatocyte proliferation and mitosis.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report

Research Products

(4 results)

All Other

All Publications (4 results)

  • [Publications] 串畑史樹: "再生肝におけるbFGF受容体の機能と抑制因子に関する検討"日本外科学会雑誌. 100. 415 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] F.Kushihata, T.Tohyama, K.Honda, N.Kobayashi: "Localization and its inhibitory factor of bFGF binding sites in regenerating rat liver."Nihon gekagakkai zasshi. 100. 415 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 串畑史樹,藤山泰二,本田和男,小林展章: "再生肝におけるbFGF受容体の機能と抑制因子に関する検討"日本外科学会雑誌. 100・臨時増刊号. 415 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 串畑 史樹: "再生肝におけるbFGF受容体の機能と抑制因子に関する検討"日本外科学会雑誌. 100. 415 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-03-31   Modified: 2016-04-21  

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