| Project/Area Number |
11671252
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
IKEDA Yoichi Faculty of Medicine, Kyushu University, Department of Surgery and Sciences, Assistant, 医学部・附属病院, 助手 (50311840)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Koaru Faculty of Medicine, Kyushu University, Department of Surgery and Sciences, Assistant, 医学部・附属病院, 助手 (70234276)
大野 真司 九州大学, 医学部, 助手 (50203881)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1999: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | Esophageal cancer / Cyclin E / Clinicopathologic features / PCNA / Cyclin D1 / Cyclin D1 |
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| Research Abstract |
We immunohistochemically analyzed expression levels of both of two major G1 Cyclins, Cyclin D1 and E, using continuous sections obtained from 111 cases of squamous cell carcinoma in the esophagus. Cyclin E overexpression correlates well with massive and invasive tumor growth and, consequently, to a poor patient outcome. Cells with a high level of Cyclin E were distributed mainly in the lower margins of the tumors, areas considered to be composed of actively cycling cells. Proliferating cell nuclear antigen (PCNA) expression showed a striking coincidence with Cyclin E-positive cells. Cyclin D1 levels showed no correlation with tumor growth and clinical prognosis. Moreover, analyzing concomitant early lesions, which are thought to be chronologically early versions of main tumors, we found that invasive and massive tumors have a tendency to be accompanied by early lesions high in Cyclin E, which suggest that the overexpression of Cyclin E may confer a higher growth activity on esophageal cancer in relatively early stages. In esophageal cancer, Cyclin E overexpression correlates well with malignant tumor growth and a poor patient outcome. Overexpression of Cyclin E can be regarded as a prognostic marker in esophageal cancer.
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