| Project/Area Number |
11671263
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
SHIMADA Hiroshi (2001) Yokohama City Univerisity, Department of Surgery, Professor, 医学部, 教授 (90117747)
長堀 薫 (1999-2000) 横浜市立大学, 医学部・附属病院, 講師 (00137035)
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| Co-Investigator(Kenkyū-buntansha) |
TOGO Shinji Yokohama City Univerisity, Department of Surgery, Assistant Professor, 医学部, 助教授 (10244477)
嶋田 紘 横浜市立大学, 医学部, 教授 (90117747)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | hepatocellular carcinoma / multicentricity / intrahepatic metastasis / survival rate / HBV-DNA integration pattern / nm23-H1 gene / p53 gene / nm23-H1遺伝子 / TAI / p^<53>遺伝子 |
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| Research Abstract |
<Purpose>
The aim of this study was to differentiate metachronously multicentric occurring hepatocellular carcinoma (MC) from intrahepatic metastatic HCC (IM) and to clarify clinical characteristics of them.
<Materials and methods>
Among 110 HCC patients with solitary nodules in the diameter of less than 5 cm having no capsular invasion and portal thrombus, 45 had recurrence. Recurrent HCC of twenty-nine patients were studied. Histological criteria and molecular biological criteria using HBV-DNA integration pattern, p53 mutation pattern and nm23-H1 expression were applied to define the multicentricity.
<Results>
1. MC was defined in 14 patients (61 %), IM in 9 (39 %) and unclassified cases was in 6. Among 23 patients 16 was defined histologically and 7 was molecular biologically.
2. Solitary recurrence were found in 1 of 9 (11 %) IM patients and 11 of 14 (80 %) MC patients, respectively (p < 0.05), well-differentiated HCC were found in 0 of 9 (0 %) and 8 of 14 (57 %), respectively (p < 0.05). Interval time between the hepatectomy and recurrence were 13.5 months in IM and 26.7 months in MC, respectively (p < 0.05).
<Conclusion>
1. MC was defined in 14 patients (61 %) and IM in 9 (39 %).
2. From the clinical viewpoint solitary well-differentiated HCC which was detected 2 years after the hepatectomy might be MC.
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