| Project/Area Number |
11671269
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Saitama Medical School |
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Principal Investigator |
MURAKAMI Saburo Saitama Medical School Department of Medicine Associate Professor, 医学部, 助教授 (00240987)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAYAMA Renzo Saitama Medical School Department of Medicine Professor, 医学部, 教授 (10014317)
TSUJI Yoshitaka Saitama Medical School Department of Medicine Lecturer, 医学部, 講師 (40227400)
SAKATA Hideto Saitama Medical School Department of Medicine Lecturer, 医学部, 講師 (10255101)
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| Project Period (FY) |
1999 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | gastric cancer / Il-2R / Tac antigen / cytokine / Colorectal cancer / Intestinal immune system |
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| Research Abstract |
In the present study, we investigated the clinical significance of serum sIL-2R in patients with early gastric cancer. 215 patients with gastric cancer were enrolled in this study. Levels of serum soluble IL-2R were measured by an enzyme-linked immunosorbent assay. The levels of sIL-2R in cases with metastatic lymph nodes were significantly higher than those without metastatic lymph nodes. Moreover, Levels of serum sIL-2R in 74 patients with early gastric cancer were measured. Five of these 6 cases with metastatic lymph nodes demonstrated positive levels of serum soluble IL-2R, while 43 of 68 cases without metastatic lymph nodes demonstrated negative levels of serum sIL-2R. In the tissues obtained from 19 cases, immunohistochemical staining was performed with mouse anti-human interleukin-2 receptor antibody. 13 of 19 cases showed Il-2R positive cells in gastric cancer tissues. Similarly, Il-2R positive cells were recognized in the tissues of metastatic lymph nodes. These results may suggest that activated T lymphocytes infiltrating into the cancer tissues play an atitumor role and release a large amount of sIL-2R, resulting the high levels of serum sIL-2R in patients with gastric cancer. Moreover, we could get the same results in colorectal cancer as in gastric cancer. According to these data, T-lymphocytes, stimulated by humoral mediator released from cancer cells, would become to be activated T-lymphocytes, resulting in the anti-tumor effects in gastrointestinal cancer.
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