| Project/Area Number |
11671283
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SASAJIMA Koji Department of Surgery I, Nippon Medical School, Associate professor, 医学部, 助教授 (80158930)
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| Project Period (FY) |
1999 – 2000
|
| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | esophageal cancer / sepsis / cytokine / apoptosis / soluble receptor / tumor necrosis factor |
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| Research Abstract |
Tumor necrosis factor-alpha (TNF-α) causes an inflammatory response by regulating the inhibitory activities of soluble tumor necrosis factor receptors (sTNFRs) after major surgery in patients with or without sepsis. The circulating blood concentrations of cytokines, sTNFRs and proteinases were measured by ELISA or EIA in patients who underwent esophagectomy. In the patients with and without sepsis, the levels of cytokines, proteinases and sTNFRs increased after surgery. The IL-6 level correlated with the levels of sTNFRs and elastase. In the patients with sepsis, the levels of TNF-α and sTNFRs were higher than those in the patients without sepsis. In contrast, the sTNFRs/TNF- α ratio was significantly lower in the patients with sepsis than in those without sepsis. These results suggest that increases in sTNFRs correlate with increases in IL-6 and proteinases, and that decreases in the sTNFRs/TNF-α ratios may result in inflammation and tissue injury in patients after esophagectomy.
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