| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
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| Research Abstract |
To determine the optimal reconstruction after total gastrectomy for cancer, nutritional assessment was performed periodically after the operation.
After obtaining adequate informed consent, 30 patients younger than 70 years of age who had undergone total gastrectomy with curative resection were classified into the following 3 groups according to the type of reconstruction; Group A, jejunal interposition (n=10); Group B, Jejunal pouch interposition (n=10); Group C, conventional Roux-en-Y procedure (n=10). The subjects were interviewed and examined periodically to assess their symptoms, food intake, body weight, and serum nutritional parameters. The plasma concentrations of the essential fatty acid were also examined 6 to 12 months postoperatively.
As regards food intake in a single meal, Group B was superior compared to the other 2 groups. The development of body weight was limited in 85-90% of the pre-illness weight, and no significant differences were found. The variations of nutritional parameters such as total protein, albumin and total cholesterol remained almost completely within normal limits throughout the follow-up periods and no significant differences were found among the 3 groups. However, the total cholesterol level in 3 groups decreased after operation and remained at significantly lower levels even 24 months after operation. The plasma levels of the essential fatty acid (ω3, ω6) were slightly higher in groups with physiological route, although no significant difference. The deficiency of essential fatty acids was not found in all patients of these groups.
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