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Nutritional assessment in terms of the reconstruction after total gastrectomy for cancer

Research Project

Project/Area Number 11671284
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKansai Medical University

Principal Investigator

NAKANE Yasushi  Kansai Medical University Faculty of Medicine Associate Professor, 医学部, 助教授 (60155778)

Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Keywordstotal gastrectomy / Reconstruction / Nutrition / essential fatty acids
Research Abstract

To determine the optimal reconstruction after total gastrectomy for cancer, nutritional assessment was performed periodically after the operation.
After obtaining adequate informed consent, 30 patients younger than 70 years of age who had undergone total gastrectomy with curative resection were classified into the following 3 groups according to the type of reconstruction; Group A, jejunal interposition (n=10); Group B, Jejunal pouch interposition (n=10); Group C, conventional Roux-en-Y procedure (n=10). The subjects were interviewed and examined periodically to assess their symptoms, food intake, body weight, and serum nutritional parameters. The plasma concentrations of the essential fatty acid were also examined 6 to 12 months postoperatively.
As regards food intake in a single meal, Group B was superior compared to the other 2 groups. The development of body weight was limited in 85-90% of the pre-illness weight, and no significant differences were found. The variations of nutritional parameters such as total protein, albumin and total cholesterol remained almost completely within normal limits throughout the follow-up periods and no significant differences were found among the 3 groups. However, the total cholesterol level in 3 groups decreased after operation and remained at significantly lower levels even 24 months after operation. The plasma levels of the essential fatty acid (ω3, ω6) were slightly higher in groups with physiological route, although no significant difference. The deficiency of essential fatty acids was not found in all patients of these groups.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 中根恭司, 井上健太郎, 飯山仁, 他: "胃全摘後空腸pouchによる代用胃作製手術"臨床外科. 54(3). 295-299 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 中根恭司, 日置紘士郎: "胃全摘後の無胃症状に対する対策-空腸Pouch間置再建術-"消化器科. 29(4). 419-425 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 中根恭司, 山中英治, 日置紘士郎: "胃癌の手術例における静脈・経腸栄養"日本臨床. 59(5). 497-500 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakane Y, Michiura T, Inoue K, et al.: "A randomized clinical trial of pouch reconstruction after total gastrectomy for cancer : Which is the better technique, Roux-en-Y or interposition?"Hepato-Gastroenterology. 48. 903-907 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 中根恭司, 道浦拓, 三宅岳, 他: "胃全摘後の空腸パウチ(食道側)間置再建術式"消化器外科. 26(2). 169-173 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakane Y, Michiura T, Inoue K, et al.: "A randomized clinical trial of pouch reconstruction after total gastrectomy for cancer: Which is the better technique, Roux-en-Y or interposition?"Hepato-Gastroenterology. 48. 903-907 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary

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Published: 1999-04-01   Modified: 2016-04-21  

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