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Research for reconstruction of anal function using electrical stimulation of transplanted gracilis muscle after resection of rectal cancer

Research Project

Project/Area Number 11671285
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKansai Medical University

Principal Investigator

YOSHIOKA Kazuhiko  Kansai Medical University Faculty of Medicine Assistant Professor, 医学部, 講師 (30166912)

Co-Investigator(Kenkyū-buntansha) TAKADA Hideho  Kansai Medical University Faculty of Medicine Associate Professor, 医学部, 助教授 (30131444)
日置 紘士郎  関西医科大学, 医学部, 学長 (60077641)
Project Period (FY) 1999 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2002: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 2001: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 2000: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1999: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordscancer or the rectum / transplantation of the gracilis muscle / anal function / abdominal stoma / 大腿薄筋移植
Research Abstract

1) Methodological establishment for physiological and anatomical studies
We have been able to prepare all equipments for physiological and anatomical studies for patients with anorectal functional disorders. We have established techniques for measurement of anorectal physiology and defecography. We measured anal pressure, anorectal inhibitory reflex, rectal sensation and threshold of anal mucosal sensation. Parameters for defecography were anorectal angle, anal canal length, pelvic floor descent and perineal descent.
2) Establishment of operative procedure and psychological assessments for patients with rectal cancer
We have carried out this new procedure in 8 patients with rectal cancer. We have also carried out graciloplasty using electrical stimulator in 4 patients with fecal incontinence. We have been able to establish the operative procedures without any operative death or major complications over the last 4 years. Informed consent has been obtained from all patients who wished to ha … More ve this operation. Psychological impact of having permanent abdominal stoma and possible disordered defecation after the operation were assessed using scenario based questionnaire in patients who was the candidates of this operation and those who had previously undergone abdominoperineal resection. The assessments revealed that although body image without having permanent abdominal stoma is clearly important for patients they also seemed to value good anal functional after this new operation.
3) Assessments of anal function
Clinical, physiological and anatomical assessments were carried out before and after the operation. We measured the functional parameters preoperatively. The same assessments were carried out before and after the electrical stimulation of the gracilis muscle and after closing the covering stoma. We have found that resting anal canal pressure increased after electrical stimulation. Clinical assessment revealed that 5 of 7 patients whose covering stoma had been closed achieved good functional results. Less

Report

(5 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] 吉岡和彦, 中野雅貴, 今田世紀, 岩本慈能, 吉田良, 高田秀穂, 日置紘士郎: "直腸癌患者に対する腹会陰式直腸切断術およびdynamic graciloplastyによる会陰部肛門の造設"手術. 54. 544-546 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 吉岡和彦, 中野雅貴, 米倉康博, 岩本慈能, 越路みのり, 吉田良: "直行癌術後の局所再発に対するdynamic graciloplastyの試み"手術. 55. 1961-1963 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K. Yoshioka, M, Nakano, S. Imada, S, Iwamoto, R. Yoshida, K. Hioki: "Construction of perinea anus with dynamic graciloplasty after abdominoperineal resection in patients with rectal cancer"Operation. 54. 544-546 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K. Yoshioka, M, Nakano, H. Yohekura, S. Iwamoto, M. Koshiji, R. Yoshida: "Dynamic graciloplasty for patients with local recurrence after operation of rectal cancer"Operation. 55. 1961-1963 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 吉岡和彦, 中野雅貴, 今田世紀, 岩本慈能, 吉田良, 高田秀穂, 日置紘士郎: "直腸癌患者に対する腹会陰式直腸切断術およびdynamic graciloplastyによる会陰部肛門の造設"手術. 54巻4号. 544-546 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] 吉岡和彦, 中野雅貴, 米倉康博, 岩本慈能, 越路みのり, 吉田良: "直行癌術後の局所再発に対するdynamic graciloplastyの試み"手術. 55巻12号. 1961-1963 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 吉岡和彦, 中野雅貴, 今田世紀, 岩本慈能, 吉田良, 高田秀穂, 日置紘士郎: "直腸癌患者に対する腹会陰式直腸切断術およびdynamic graciloplastyによる会陰部肛門の造設"手術. 54巻4号. 544-546 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 吉岡和彦, 中野雅貴, 米倉康博, 岩本慈能, 越路みのり, 吉田良: "直行癌術後の局所再発に対するdynamic graciloplastyの試み"手術. 55巻12号. 1961-1963 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 吉岡和彦,中野雅貴,今田世紀,岩本慈能,吉田良,高田秀穂,日置紘士郎: "直腸癌患者に対する腹会陰式直腸切断術およびdynamic graciloplastyによる会陰部肛門の造設"手術. 54巻4号. 544-546 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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