| Project/Area Number |
11671289
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | HYOGO COLLEGE OF MEDICINE |
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Principal Investigator |
YAMANAKA Junichi Hyogo College of Medicine Assistant Professor, 医学部, 助手 (90289083)
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| Co-Investigator(Kenkyū-buntansha) |
YASUI Chiaki Hyogo College of Medicine Assistant Professor, 医学部, 助手 (10291816)
TANAKA Tsuneo Hyogo College of Medicine Assistant Professor, 医学部, 講師 (80248137)
YAMANAKA Naoki Hyogo College of Medicine Associate Professor, 医学部, 助教授 (90131599)
KURODA Nobukazu Hyogo College of Medicine Assistant Professor, 医学部, 助手 (20301658)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
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| Keywords | liver transplantation / aging / rat / ラット / 加齢 |
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| Research Abstract |
AIM : Liver transplantation (LT) using grafts from aged donors has been widely performed because of donor organ shortage. However, there have been few detailed studies, reporting the influence of aging problem in LT.The aim of this study was to investigate morphological and functional changes of aged liver grafts transplanted into young recipients and influence of graft aging on recipient growth.MATERIALS ＆ METHODS : LT was performed using male Fischer rats. Hepatocyte morphometry, liver function parameters, and recipient body weight were compared between the following two groups at 4 months after LT.In Group I (n=20), liver grafts harvested from young rats of 11 weeks of age were implanted into 11-week rats.In Group II (n=2O), grafts from old rats of 52 weeks of age were implanted into11-week rats. RESULTS : Although serum T-Bil and ALT levels were comparable between the two groups, albumin was significantly lower in Group II than in Group I (p<0.05). Nuclear/cytoplasm ratio was comparable between the two groups, whereas multinuclear cells were more frequently observed in Group II than in Group I (p<0.05). Body weight gain was significantly lower in Group II than in Group I (p<0.05). CONCLUSIONS : Transplanted rat liver grafts showed morphological and functional changes based on the graft age, but not on the host age. Implication of retarded recipient growth after aged liver grafting remains to be clarified.
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