| Project/Area Number |
11671293
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kurume University |
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Principal Investigator |
KAIBARA Atsushi Kurume University, Medicine, Faculty of medicine Assistant, 医学部, 助手 (20204315)
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| Co-Investigator(Kenkyū-buntansha) |
TAJIRI Tetsurou Kurume University, Medicine, Faculty of medicine Assistant, 医学部, 助手 (10299464)
KAMEI Hideki Kurume University, Medicine, Faculty of medicine Assistant, 医学部, 助手 (10268899)
YOSHIDA Shogo Kurume University, Medicine, Faculty of medicine Assistant, 医学部, 助手 (30191589)
ISHIBASHI Nobuya Kurume University, Medicine, Faculty of medicine Assistant, 医学部, 助手 (90248427)
岡 洋右 久留米大学, 医学部, 助手 (30320211)
田中 克明 久留米大学, 医学部, 助手 (40299467)
村岡 達也 久留米大学, 医学部, 助手 (20299499)
山崎 国司 久留米大学, 医学部, 助手 (00200642)
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| Project Period (FY) |
1999 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | cancer cachexia / Brain cytokine expression / tube feeding / 中枢神経 / 悪性腫瘍 / サイトカイン / 強性栄養 / アミノ酸代謝 / 腫瘍転移 / 腫瘍増殖 / 糖代謝 / 担癌マウス / 経腸栄養 / 悪液質 |
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| Research Abstract |
Previous study have shown that cytokine mRNA expression is elevated in the brains of anorectic, tumor bearing rats. The projects of the current study were as follows : 1) to determine whether a small tumor would result in up-regulation of tumor necrosis factor (TNF-α) and interleukin 1b (IL-1β) mRNA expression in the brain and other tissues of tumor bearing mice and 2) to determine whether hyperalimentation by tube feeding would prevent up-regulation of cytokine mRNA expression in the brain and other tissues of tumor-bearing mice. Methods ; Male C57BL/6 mice were divided into 4 groups : 1) control mice fed ad libitum (Control), 2) tumor bearing mice fed ad libitum (TB), 3) control mice receiving tube feeding (CTF), 4) tumor bearing mice receiving tube feeding (TBTF). Results ; TNF-α and IL-1β mRNA expression was elevated in the brains of mice with 1% body weight tumor, relative to the control and CTF groups, without any detectable changes in the other organs. On the other hand, TNF-α and IL-1β mRNA expression in all the organs of mice was elevated with 8% body weight tumor, relative to the control and CTF groups. Tube feeding did not change TNF-α and IL-1β mRNA expression in mice burdened with either a 1% or 8% body weight tumor. Conclusion : Up-regulation of cytokine mRNA synthesis occurs earlier in the brain than in other organs, and hyperalimentation does not change in cytokine mRNA expression in tumor bearing mice. Therefore, it is very important to elucidate mechanisms of up-regulation of cytokine mRNA in the brain in tumor bearing mice to prevent cancer cachexia.
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