| Project/Area Number |
11671301
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Yamagata University |
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Principal Investigator |
WATANABE Takao Yamagata Univ., Med., Associate Professor, 医学部, 助教授 (60138922)
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| Co-Investigator(Kenkyū-buntansha) |
INUI Kiyoshige Yamagata Univ., Med., Assistant Professor, 医学部, 助手 (70250941)
SHIMAZAKI Yasuhisa Yamagata Univ., Med., Professor, 医学部, 教授 (60116043)
高橋 俊樹 山形大学, 医学部, 講師 (50263257)
箕輪 隆 山形大学, 医学部, 助手 (50292420)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | evoked potential / glutamate / paraplegia / intercostal artery / 胸部大動脈瘤手術 |
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| Research Abstract |
Paraplegia after thoracoabdominal aortic operation is very miserable complication. We must decide which intercostal artery must be reconstructed or not. But the decision making is very drfficutt. So we studied the possibility of prediction of intercostal arteries must be reconstructed.
Method: Neuron exciting aminooacid was infused to intercostal arteries by using two balloon catheters inserted from femoral artery. The evoked potential of spinal cord during infusion was measured.
Results: The change of evoked potential was recognized after the infusion of neuron exiting aminiacids. But the thereshouled for induction of potential change was very different from dog to dog. And the effect of infusion have continued for long time.
Conclusions: Although we think that the preoperative infusion of neuro exciting aminoacids may be useful of detecting intercostal aretries to be reconstructed, we could not decide whether the effect was derived by the variation of arterial network because the reaction severity was very different from dog to dog. And the long lasting effect of infusing aminoacids must be the adverse effect for clinical use.
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