• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishment of antegrade selective cerebral perfusion during aortic arch operation

Research Project

Project/Area Number 11671313
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

KAZUI Teruhisa  Hamamatsu University School of Medicine, Professor, 医学部, 教授 (20094203)

Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsThoracic aortic aneurysm / Aortic arch aneurysm / Total arch replacement / Selective cerebral perfusion / Cerebral protection / 脳梗塞 / 術後脳機能障害 / 頚静脈酸素飽和度 / Near infrared spectroscopy
Research Abstract

Objective : Patients with old cerebral infarction who undergo aortic arch operation are more susceptible to postoperative neurological dysfunction. To verify such susceptibility, this experimental study was performed. Methods : Cerebral infarct model was created in mongrel dogs by injection of cylindrical silicon embolus through the internal carotid artery. The dogs that had obvious neurological deficits one day later and survived for 4 weeks or more were included in the cerebral infarct model. One month after cerebral infarction was induced, deep hypothermia and selective cerebral perfusion were employed in fourteen mongrel dogs (Infarct group 7, Control group 7). During this procedure, serum glutamate concentration and venous-arterial lactate difference were measured. Histopathological study of the brain was also performed. Results : Changes in venous-arterial lactate difference in both groups were almost similar except in rewarming phase. At 32℃ during rewarming, venous-arterial lactate difference in the Infarct group was significantly higher than that in the Control group (p=0.006). Although pre-cooling concentrations of serum glutamate were similar in both groups, the values in the Infarct group at the end of rewarming were significantly higher than those in the Control group (p=0.046). On histological examinations, the presence of old cerebral infarction with gliosis was confirmed in the Infarct group but neither new cerebral infarction nor destruction of blood brain barrier was found. Conclusion : We have observed an accelerated anaerobic metabolism and an increased extracellular glutamate release in the Infarct group. The brain with old cerebral infarction is more susceptible to ischemia during arch operation.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] Kazui T,et al.: "Total arch replacement using aortic arch branched grafts with the aid of antegrade selective cerebral perfusion."Ann Thorac Surg. 70. 3-8 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Washiyama N,et al.: "A newly developed cerbral perfusion catheter for aortic arch operation."J Artif Organ. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Wahiyama N,et al.: "Experimental study on the effect of antegrade cerebral perfusion on brain with old cerebral infarction."J Thoracic Cardiovasc Surg. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Dossche KM, Schepens MAAM, Morshuis WJ, Muysoms FE, Lagemeijer JJ, Vermeulen FEE.: "Antegrade selective cerebral perfusion in operations on the proximal thoracic aorta."Ann Thorac Surg. 67. 1904-10 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kazui T, Washiyama N, Muhammad BAH, Terada H, Yamashita K, Takinami M, et al.: "Extended total arch replacement for acute type A aortic dissection : Experience with seventy patients."J Thorac Cardiovasc Surg. 119. 558-65 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Roach GW, Kanchuger M, Mangano CM, Newman M, Nussmeier N, Wolman R, et al.: "Adverse cerebral outcomes after coronary bypass surgery."N Engl J Med. 335. 1857-63 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Svensson LG, Crawford ES, Hess KR, Coselli JS, Raskin S, Shenaq SA, et al.: "Deep hypothermia with circulatory arrest ; determinants of stroke and early mortality in 656 patients."J Thorac Cardiovasc Surg. 106. 19-31 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sakurada T, Kazui T, Tanaka H, Komatsu S.: "Comparative experimental study of cerebral protection during aortic arch reconstruction."Ann Thorac Surg. 61. 1348-54 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Swain JA, Macdonald TJ, Griffith PK, Balaban RS, Clark RE, Ceckler T, et al.: "Low-flow hypothermic cardiopulmonary bypass protects the brain."J Thorac Cardiovasc Surg. 102. 76-84 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kazui T, Washiyama N, Muhammad BAH, Terada H, Yamashita K, Takinami M, et al.: "Total arch replacement using aortic arch branched grafts with the aid of antegrade selective cerebral perfusion."Ann Thorac Surg. 70. 3-8 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Molinari GF.: "Experimental cerebral infarction. I.Selective segmental occlusion of intra cranial arteries in the dog."Strok. 1. 224-31 (1970)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Molinari GF.: "Experimental cerebral infarction. II.Clinicopathological model of deep cerebral infarction."Stroke. 1. 232-44 (1970)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Torre EDL, Netsky MG, Meschan I.: "Intracranial and extracranial circulation in the dog : anatomic and angiographic studies."Amer J Anat. 105. 343-81 (1959)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Smith AL, Hoff JT, Nielsen SI, Lason P.: "Barbiturate protection in acute focal cerebral ischemia."Stroke. 5. 1-7 (1974)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Clark RK, Lee EV, Fish CJ, White RF, Price WJ, Jonak ZL, et al.: "Development of tissue damage, inflammation and resolution following stroke : an immunohistochemical and Quantitative planimetric study."Brain Research Bulletin. 31. 565-72 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Bosley TM, Woodhams PL, Gordon RD, Belazs R.: "Effects of anoxia on the stimulated release of amino acid neurotransmitters in the cerebellum in vitro."J Neurochem. 40. 189-201 (1983)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hansen AJ.: "Effect of anoxia on ion distribution in the brain."Physiol. 65. 101-148 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takagi K, Ginsberg MD, Globus MYT, et al.: "Changes in amino acid neurotransmitters and cerebral blood flow in the ischemic penumbral region following middle cerebral artery occlusion in the rat : correlation with histopathology."J Cereb Blood Flow Metab. 13. 575-85 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Castillo J, Davalos A, Noya M.: "Progression of ischemic stroke and excitotoxic aminoacids."Lancet. 349. 79-83 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Dirnagl U, Pulsinelli W.: "Autoregulation of cerebral blood flow in experimental focal brain ischemia."J Cereb Blood Flow Metab. 10. 327-36 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Paulson OB.: "Regional cerebral blood flow in apoplexy due to occlusion of the middle cerebral artery."Neurology. 20. 63-77 (1970)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Watanabe T, Oshikiri N, Inui K, Kuraoka S, Minowa T, Hosaka J, et al.: "Optimal blood flow for cooled brain at 20℃."Ann Thorac Surg. 68. 864-9 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kazui T, Washiyama N, Muhammad BAH, Terada H, Yamashita K, Takinami M.: "Improved results of atherosclerotic arch aneurysm using a refined technique."J Thorac Cardiovasc Surg. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Steen PA, Newberg LA, Midle JH, Michenfelder JD.: "Hypothermia and barbiturates : Individual and combined effects on canie cerebral oxygen consumption."Anesthesiology. 58. 527-32 (1983)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Michenfelder JD, Milde JH.: "The relationship among canine brain temperature, metabolism, and functtion during hypothermia."Anesthesiology. 75. 130-6 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ohmi M, Tabayashi K, Hata M, Yokoyama H, Sadahiro M, Saito H.: "Brain damage after aortic arch repair using selective cerebral perfusion."Ann Thorac Surg. 66. 1250-3 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Miyamoto K, Kawashima Y, Matsuda H, Okuda A, Maeda S, Hirose H.: "Optimal perfusion flow rate for the brain during deep hypothermic cardiopulmonary bypass at 2O℃."J Thorac Cardiovasc Surg. 92. 1065-70 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tanaka H, Kazui T, Sato H, Inoue N, Yamada O, Komatsu S.: "Experimental study on the optimum flow rate and pressure for selective cerebral perfusion."Ann Thorac Surg. 59. 651-7 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tanaka J, Shiki K, Asou T, Hisataka Y, Tokunaga K.: "Cerebral autoregulation during hypothermic nonpulsatile cardiopulmonary bypass with selective cerebral perfusion in dogs."J Thorac Cardiovasc Surg. 95. 124-32 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Albers GW, Goldberg MP, Choi DW.: "N-methyl-D-asparate antagonists : ready for clinical trial in brain ischemia?"Ann Neurol. 25. 398-403 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Washiyama N. et al: "Experimental study on the effect of antegrade cerebral perfusion on brain with old cerebral infarction"Journal of Thoracic and Cardiovascular Surgery. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Kazui T. et al: "improved results of atherosclerotic arch aneurysm operations with a refined technique"Journal of Thoracic and Cardiovascular Surgery. 121. 491-499 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kazui T. et al: "Total arch replacement using aortic arch branched grafts with the aid of antegrade selective cerebral perfusion"Annals of Thoracic Surgery. 70. 3-9 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Washiyama N. et al: "A newly developed cerebral perfusion catheter for aortic arch operation"Journal of Artificial Organ. (in press).

    • Related Report
      2000 Annual Research Report

URL: 

Published: 1999-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi