| Project/Area Number |
11671324
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | OKAYAMA UNIVERSITY |
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Principal Investigator |
SANO Shunji OKAYAMA UNIVERSITY, MEDICAL SHOOL, PROFESSOR, 医学部, 教授 (50235438)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | non-heart-beating donor / heart transplantation / heart preservation / normothermic ischemia / reperfusion injury / cardiac function / nicorandil / 虚血再灌流 / 再潅流 |
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| Research Abstract |
Objective ; To expand the donar pool, we evaluate the effect of nicorandil, an adenosine triphosphatesensitive potassium channel opener-nitrate, on the early post-transplant cardiac function in the setting of heart transplantation from non-heart-beating donnors. Subjects and Method ; hypoxic cardiac arrest was induced in 12 donor dogs. In six dogs, nicorandil (100 microgram/kg+25 microgram /kg/min) was administered intravenously after respiratory arrest and preserved (Nicorandil group). The other 6 donors whitch received no treatments were served as control (Control group). These hearts were orthotopiccally transplantated.
Results ; post-transplant left ventricular end-systolic pressure (99±19 vs. 72±16mmHg, p=0.026), max positive dp/pt (2016±607 vs. 1152±570mmHg/sec, p=0.029) and cardiac index (2.8±1.1 vs. 1.5±0.5 L/min/m2, P=0.027) in Nicorandil group were significantly greater than those inControl group.
Conclusions ; These results suggest that nicorandil ameliorates early post-transplant left ventricular function harvested from no n-heart-beating donors. Therefore nicorandil may be one of potent cadioprotective agent in this setting.
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