Sugical strategy for thoracic pain syndrome -experiment of bone formation by rhBMP-2-
Project/Area Number |
11671377
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cerebral neurosurgery
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Research Institution | Nara Medical University |
Principal Investigator |
MORIMOTO Tetsuya Nara Medical University, Associate Professor, 医学部, 助教授 (50210191)
|
Co-Investigator(Kenkyū-buntansha) |
IDA Yuki Nara Medical University, Research Associate, 医学部, 助手 (60316065)
|
Project Period (FY) |
1999 – 2000
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Project Status |
Completed (Fiscal Year 2000)
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Budget Amount *help |
¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2000: ¥300,000 (Direct Cost: ¥300,000)
|
Keywords | rhBMP-2 / thoracic pain / osteoporosis / bone formation / 骨癒合 / 犬 / 骨新生促進 |
Research Abstract |
Simultaneous measurements of spinal cord blood flow and arterial diameter at areas adjacent to a site of spinal cord injury were carried out to determine changes in CO_2 reactivity and autoregulation. The spinal cord injury was made at T10 level by the epidural clip compression method. A spinal window was drilled at an area either 7mm caudal or 7mm rostral to the injury site for the measurement of spinal cord blood flow and arterial diameter at the same time. Spinal cord blood flow was decreased at both spinal windows, especially at the rostral window. Arterial diameter was also decreased significantly at both sites. The ischaemic zone evaluated histologically tended to expand more diffusely in the rostral direction than in the caudal direction. In the pre-injury stage, both CO_2 reactivity and autoregulation were present in the spinal cord. Following the clip injury, CO_2 reactivity and autoregulation were both impaired in the areas 7mm adjacent to the impact site. Correlation coefficients suggested that the rostral spinal cord tended to sustain more injury than the caudal spinal cord. The histologically proven spinal cord ischaemia following the injury may have resulted from the decreased arterial diameter and impaired CO_2 reactivity and dysautoregulation of the spinal cord.
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Report
(3 results)
Research Products
(24 results)