| Project/Area Number |
11671380
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
ITAKURA Toru Wakayama Medical University, Professor, 医学部, 教授 (40100995)
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| Co-Investigator(Kenkyū-buntansha) |
中尾 直之 和歌山県立医科大学, 医学部, 助手 (30301435)
上松 右二 和歌山県立医科大学, 医学部, 講師 (90223502)
中井 國雄 和歌山県立医科大学, 医学部, 助教授 (20180234)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Parkinson disease / transplant / sympathetic ganglion / 細胞移植 |
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| Research Abstract |
In the present research project we have investigated effect of transplantation of autologous sympathetic ganglion into the brain on parkinsonian symptoms. We also studied clinical research for deep brain stimulation of the globus pallidus in Parkinson patients.
Fifty percent of the patients receiving transplantation of sympathetic ganglion showed improvement of parkinsonian symptoms such as gait disturbance and bradykinesia. However, the patients did not show improvement of muscle rigidity and tremor after transplantation. These effects continued up to 6 years after transplantation.
Chronic electrical stimulation of the globus pallidus was performed in 20 patients with Parkinson disease. About 60% of the patients showed improvement of Parkinson symptoms, especially drug-induced dyskinesia, muscle rigidity and bradykinesia. Neurotransmitters such as GABA, dopamine and other catecholamines were measured during electrical stimulation of the globus pallidus, which showed elevation of GABA in the ventricular fluid 1hr after stimulation.
These studies clearly demonstrated the effects of transplantation and deep brain stimulation on symptoms in patients with Parkinson disease.
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