| Project/Area Number |
11671410
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
ITO Manabu Hokkaido Univ., Grad. School of Med., Inst., 医学部・附属病院, 助手 (00271677)
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| Co-Investigator(Kenkyū-buntansha) |
KOTANI Yoshihisa Hokkaido Univ., Grad. School of Med., Inst., 医学部・附属病院, 助手 (40312368)
SHONO Yasuhiro Hokkaido Univ., Grad. School of Med., Assist. Prof., 医学部・附属病院, 講師 (80261288)
TANEICHI Hitoshi Hokkaido Univ., Grad. School of Med., Assist. Prof., 医学部・附属病院, 講師 (10261299)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Hemodialysis / Destructive Spondyloarthropathy / Immunology / Histology / Surgical Treatment |
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| Research Abstract |
This study clarified the mechanisms of severe destructive changes in the spinal components in patients treated with long-term hemodialysis. Distribution of amyloid deposition and destruction of facet joints and disc-body unit were manifested through this project. At site of severe body destruction in vertebral bodies, the activity of osteoclasts was enhanced and that of osteoblasts was completely suppressed. This local pathology played an important role in establishment of server spinal destructive changes. The ideal spinal reconstruction procedures were proposed and the clinical outcomes in cervical reconstruction were published in the international journal of Spine. The results of this strudy were accepted for presentation in many international meetings or symposiums. Spinal fusion rate and surgery success rates were dramatically improved by our invented surgical procedures. This study had a great contribution for the establishment of secure spinal reconstruction surgery for the patients suffering destructive spondyloarhtropathy associated with long-term hemodialysis.
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