| Project/Area Number |
11671412
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Akita Unuversity |
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Principal Investigator |
SHIMADA Yoichi Akita University, School of Medicine, Associate Professor, 医学部, 助教授 (90162685)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUNAGA Toshiki Akita University, School of Medicine, Research Professor, 医学部, 助手 (50312715)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2001: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2000: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | FES / Muscle fatigue / High frequency Stinulation |
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| Research Abstract |
We evaluated the effects of high frequency electrical stimulation for preventing acute muscle atrophy after spinal cord transection in rats. The lesser fiber diameters from type 1, 2A and 2B muscle fibers were measured. In another assessment, maximal contraction force was measured. The muscle force produced at 20, and 100Hz was expressed as increasing values (IV) in tetanic force. In the comparison between non-stimulated and stimulated Tibialis Anterior (TA) muscles, the atrophy of type 1 fibers (p < .01) and type 2B fibers (p < .05) at both stimulated levels and of type 2A fibers at 100Hz level (p < .05) were preventedby therapeutic electrical stimulation (TES). There were significant differences in the size of muscle fiber diameter between non-stimulated and stimulated muscles at 100 Hz in type 2A and, markedly, in type 2B. The increasing value of muscle force was significantly greater at 100Hz than at 20Hz (p < .05). No significant histological differences were observed between high and low frequency stimulated fibers of any of the three muscle types. We concludes that acute atrophy of muscle fibers was more effectively prevented by high (100Hz) frequency stimulation than no or low (20Hz) frequency stimulation, and the increasing value of muscle force was significantly greater at high frequency stimulation than low frequency stimulation, suggesting that future studies, including the clinical application of high frequency stimulation to acute spinal cord injury, should be conducted.
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