Periteral nerve elongation for nerve repair
| Project/Area Number |
11671416
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
TSUJINO Akihito Institute of Clinical Medicine, University of Tsukuba, Associate professor, 臨床医学系, 助教授 (30272199)
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| Co-Investigator(Kenkyū-buntansha) |
落合 直之 筑波大学, 臨床医学系, 教授 (30134563)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1999: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | nerve elongation / nerve repair / nerve injury / nerve regeneration |
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| Research Abstract |
In an experimental study in rats we tested treatment of a peripheral nerve gap by incremental stretch to lengthen the nerve. An external fixator was used to progressively lengthen the femur, and consequently the sciatic nerve, by 3 mm/day (group 3 mm) or 5mm/day (group 5 mm). In both groups, total lengthening was 15mm. Seven days after initiating nerve lengthening, the external fixator was removed and the nerve was transected and sutured. At 2, 4, 6, or 8 weeks after this suturing, semithin sections were prepared from sciatic and tibial nerves. Although regeneration of nerve fibers was observed beginning at 2 weeks, nerve regeneration showed a delay in group 5 mm at 6 weeks, when group 3 mm showed nerve regeneration as good as in the unstretched control group. Fibroblasts and myelin debris were abundant in group 5 mm. Differences in nerve regeneration after nerve lengthening at different rates were considered results of mechanical nerve injury, nerve degeneration, ischaemia, and fibrosis, all worse with more rapid lengthening. Nerve lengthening at a more moderate rate (3 mm/day) does not compromise regeneration.
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Report
(3 results)
Research Products
(5 results)
