| Project/Area Number |
11671420
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The university of Tokyo |
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Principal Investigator |
SEICHI Atsushi Dept. of Orthopedic Surgery, The University of Tokyo Lecturer, 医学部・附属病院, 講師 (70236066)
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Takahiro Dept. of Orthopedic Surgery, The University of Tokyo Lecturer, 医学部・附属病院, 講師 (20272544)
NAKAMURA Kozo Dept. of Orthopedic Surgery, The University of Tokyo Professor, 医学部・附属病院, 教授 (60126133)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1999: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | spinal cord injury / angiogenesis / Spinol cord injvry / angiogenesis / spinal cord injury |
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| Research Abstract |
The spinal cord injury was made by putting 25 g weight for 20 minutes on the dorsal surface of the spinal cord at the thoracic spine in rats. Antithrombin 3, which has a potentiality of protective effect of endothelial cells, was administered intravenously before the compression. We recorded the spinal cord evoked potentials at the thoracic spinal cord after stimulation to brain and cervical cord. Until 12 weeks after injury, we observed the recovery course of waveform and motor function. There were statistically significant differences on the motor recovery between experimental group and control group. Evoked potentials of the AT3 group recovered earlier than those of the control group. AT3 may have a positive effect on the recovery of incomplete spinal cord injury.
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