| Project/Area Number |
11671448
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KUSAKA Yoshiaki Dept.of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Lecturer, 医学部, 講師 (40205068)
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Masahiko Dept.of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Lecturer, 医学部, 講師 (60208329)
SEO Yoshiteru Dept.of Physiology, Kyoto Prefectural University of Medicine, Lecturer, 医学部, 講師 (90179317)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Achilles tendon / Water molecule / Dipolar interaction / Collagen fiber / Double-Quantum-Filtered NMR / Order of molecule / MRI |
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| Research Abstract |
The aim of this project is the quantitative evaluation of injured tendons with a new magnetic resonance imaging.
1) DQF-NMR image : At 3 weeks after tenotomy, the injured Achilles tendon was not depicted on the DQF-NMR image. But, while injured Achilles tendons are maturing, the signal from injured Achilles tendons became higher on the DQF-NMR image. With the conventional MRI, the injured tendon could not be distinguished from other normal tendons. With the DQF-NMR image, this distinction was clear by optimizing the creation time (τ).
2) DQF-NMR signal : At 3 weeks after tenotomy, the signals from injured Achilles tendons were not detected. But, while injured Achilles tendons were maturing, the intensity of DQF-NMR signals from injured Achilles tendons, which was related with the amount and the order of collagen fibers in injured Achilles tendons, became higher and t_<max> of DQF-NMR signals, which was related with the order of collagen fibers, became shorter.
3) Histological findings : While injured Achilles tendons were maturing, the order of collagen fibers in the part of injured tendon tissues became higher.
With using a DQF-NMR imaging method, the order of collagen fibers in injured tendon tissues could be evaluated quantitatively, and injured Achilles tendons at a subchronic phase could be clearly distinguished from other intact tendons.
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