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Biochemical and biomechanical analysis of irradiated allograte and remidelling of the transplantation

Research Project

Project/Area Number 11671470
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionOsaka Prefectural College of Nursing

Principal Investigator

KOUSEI Shiro  Osaka University, associate proffesor, 教授 (40135679)

Co-Investigator(Kenkyū-buntansha) HAMADA Masayoki  Osaka Prefecture College of Health Science, Professor, 医学部, 講師 (90303958)
中田 研  大阪大学, 医学部, 助手 (00283747)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsallograte / irradiation / remodeling / biomechanics / biochemical study / 靭帯再建 / 再構築 / 同種靭帯移植
Research Abstract

We focused on the effect of radiation of allogeneic tendons and remodeling process during the period of this Grant-in-Aid for Scientific Research.
1. Biochemical and biomechanical analysis of the irradiated allogeneic tendons after transplantation using rat animal model Rat allogeneic tendon/ligament transplatation model by substitution of the patellar tendon with allografts demonstrated that radiation promoted turn-over of the collagen fibril after transplantation and its effect was enhanced more in the freeze-dried tendons than in the freshfrozen. Biomechanical analysis proved that irradiation of the allogeneic tendons decreased their tensile strength after transplantation. There was no statistically difference between the freshfrozen group and in the freeze-dried one. The tensile strength of the grafts increased 6 weeks after transplantation in the both group.
2. Human clinical usage of irradiated allograft. Lateral ligaments of human ankle joint were reconstructed using irradiated allograft. Clinical study showed these patients have satisfactory stability of their ankle and good range of ankle motion after operation.
3. Biomechanical analysis of grafts using a robotic simulator Anterior cruciate ligament reconstruction via two-femoral socket provided better anterior-posterior stability compared with the conventional reconstruction using a single socket.

Report

(3 results)
  • 2001 Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Shino K. et al.: "Comparison of eccentric and concentric screw placement for hamstring graft fixation in the tibial tunnel"Knee Surgery, Sports Traumatology, Arthroscopy. 8. 73-75 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shino K. et al.: "The gravity sag view : A simple radiographic technique to show posterior laxity of the knee"Arthroscopy. 16. 670-672 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hamada M. et al.: "Chondral Injury Associated With Acute Isolated Posterior Cruciate Ligament Injury"Arthroscopy. 16. 59-63 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hamada M. et al.: "Preoperative anterior knee laxity did not influence postoperative stability restored by anterior cruciate ligament reconstruction"Arthroscopy. 16. 477-482 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hamada M. et al.: "Single-versus bi-socket ACL reconstruction using autogenous multiple-stranded hamstring tendons with EndoButton"Arthroscopy. 17. 801-807 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakata K. et al.: "Reconstruction of the lateral ligaments of the ankle using solvent-dried and gamma-irradiated allogeneic fascia lata"J.Bone joint Surg. 82B. 579-582 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fuji H., Mae T., Shino K.: "Development and application of a robbtic simulation"Kajzer J., Tainaka E., Yamada H.. 255-260 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mitsuoka, T., Shino K., et al: "Osteochondritis dissecans of the lateral femoral condyle of the knee joint"Arthroscopy. 15(1). 20-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ozkan, L, Shino K., et al: "Direct in vivo gene transfer to healing rat patellar ligament by intra-arterial delivery of haemagglutinating virus of Japan liposomes"Eur J Clin Invest. 29(1). 63-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hamada, M., Shino K., et al: "Chondral injury associated with acute isolated posterior cruciate ligament injury"Arthroscopy. 16(1). 59-63

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shino, K, and Pflaster D, S.: "Comparison of eccentric and concentric screw placement for hamstring graft fixation in the tibial tunnel"Traumatol Arthrosc. 8(2). 73-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakata, K., Shino K., et al: "Reconstruction of the lateral ligaments of the ankle using solvent-dried and gamma-irradiated allogeneic fascia lata"Surg Br. 82(4). 579-82

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hamada, M., Shino K., et al: "Preoperative anterior knee laxity did not influence postoperative stability restored by anterior cruciate ligament reconstmction"Arthroscopy. 16(5). 477-82

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shino, K., Mitsuoka T., et al: "The gravity sag view : a simple radiographic technique to show posterior laxity of the knee"Arthroscopy. 16(6). 670-2

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakamura, N., Shingo K., et al: "Decorin antisence gene therapy improves functional healing of early rabbit ligament scar with enhanced collagen fibrillogenesis in vivo"J Orthop Res. 18(4). 517-23

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Natsu-ume, T., Shino K., et al: "AEndoscopic reconstruction of the anterior cruciate ligament with quadrupled hamstring tendons. A correlation between M RI changes and restored stability of the knee"J Bone Joint Surg Br. 83(6). 834-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mae T., Shino K., et al: "Single- versus two-femoral socket anterior cruciate ligament reconstruction technique : Biomechanical analysis using a robotic gimulator"Arthroscopy. 17(7). 708-16

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hamada, M., Shino K, et al: "Single- versus bi-socket anterior cruciate ligament reconstruction using autogenous multiple-stranded hamstring tendons with endoButton femoral fixation : A prospective study"Arthroscopy. 17(8). 801-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakata, K., Shino K., et al: "Human meniscus cell : characterization of the primary culture and use for tissue engineering"Clin Orthop. (391 Suppl). S208-18

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shino,K,Pflaster,D.S.:: "Comparison of eccentric and concentric screw placement for hamstring graft fixation in the tibial tunnel."Knee Surg., Sports Traumatolog.,Arthroscopy. 8:73-75. 73-75 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakata,K.,Shino,K,Horibe,S.,Natsu-ume T.,Mae,T.,Ochi,T: "Reconstruction of the lateral ligaments of the ankle using solvent-dried and gamma-irradiated allogeneic fascia lata."J.Bone Joint Surg.. 82-B. 579-582 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hamada,M.,Shino,K,Mitsuoka,T.,Toritsuka,Y.,Natsu-ume T., et al: "Chondral injury associated with acute isolated posterior cruciate ligament injury."Arthroscopy. 16. 16:59-63 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fujie,H.,Mae,T.,Shino,K, et al.: "Development and application of a robotic simulator."Kajzer,J.,Tanaka,E.,Yamada,H.. 255-260 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T. Mitsuka: "Osteochondrizis clissecans of the lateral femoral corelyle of the"Arthroscopy. 15. 20-26 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] I. Ozkan: "Direct in vivo gene transfer of healing rat patellar ligament by intra-arterial delivery of haenaggiutingting virus of Japan liposones"Eur J. Clin Invest. 26. 63-27 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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