Biochemical and biomechanical analysis of irradiated allograte and remidelling of the transplantation
| Project/Area Number |
11671470
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka Prefectural College of Nursing |
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Principal Investigator |
KOUSEI Shiro Osaka University, associate proffesor, 教授 (40135679)
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| Co-Investigator(Kenkyū-buntansha) |
HAMADA Masayoki Osaka Prefecture College of Health Science, Professor, 医学部, 講師 (90303958)
中田 研 大阪大学, 医学部, 助手 (00283747)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | allograte / irradiation / remodeling / biomechanics / biochemical study / 靭帯再建 / 再構築 / 同種靭帯移植 |
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| Research Abstract |
We focused on the effect of radiation of allogeneic tendons and remodeling process during the period of this Grant-in-Aid for Scientific Research.
1. Biochemical and biomechanical analysis of the irradiated allogeneic tendons after transplantation using rat animal model Rat allogeneic tendon/ligament transplatation model by substitution of the patellar tendon with allografts demonstrated that radiation promoted turn-over of the collagen fibril after transplantation and its effect was enhanced more in the freeze-dried tendons than in the freshfrozen. Biomechanical analysis proved that irradiation of the allogeneic tendons decreased their tensile strength after transplantation. There was no statistically difference between the freshfrozen group and in the freeze-dried one. The tensile strength of the grafts increased 6 weeks after transplantation in the both group.
2. Human clinical usage of irradiated allograft. Lateral ligaments of human ankle joint were reconstructed using irradiated allograft. Clinical study showed these patients have satisfactory stability of their ankle and good range of ankle motion after operation.
3. Biomechanical analysis of grafts using a robotic simulator Anterior cruciate ligament reconstruction via two-femoral socket provided better anterior-posterior stability compared with the conventional reconstruction using a single socket.
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Report
(3 results)
Research Products
(25 results)
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[Publications] Nakata,K.,Shino,K,Horibe,S.,Natsu-ume T.,Mae,T.,Ochi,T: "Reconstruction of the lateral ligaments of the ankle using solvent-dried and gamma-irradiated allogeneic fascia lata."J.Bone Joint Surg.. 82-B. 579-582 (2000)
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[Publications] Fujie,H.,Mae,T.,Shino,K, et al.: "Development and application of a robotic simulator."Kajzer,J.,Tanaka,E.,Yamada,H.. 255-260 (2000)
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