| Project/Area Number |
11671493
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
YODOI Junji Kyoto University, Institute for Virus Research, Professor, ウイルス研究所, 教授 (80108993)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Hajime Kyoto University, Institute for Virus Research, Associate Professor, ウイルス研究所, 助教授 (70303914)
廣田 喜一 京都大学, 医学研究科, 助手 (00283606)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2000: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | redox / thioredoxin / glutaredoxin / cytokine / oxidative stress / cellular signal transduction / 生体応答 / レドックス制御 / ストレス反応 / MAPK |
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| Research Abstract |
Hypercytokinemia is one of the most threatening elements of stress responses against surgical insult, fulminate pancreatitis, trauma, burn, and sepsis. Now it is widely appreciated that reactive oxygen intermediates (ROIs) play critical roles in the pathophysiology of hypercytokinemia. The main aim of our project is to clarify the significance of oxido-reductive (redox) regulation of extra- and intra-cellular signaling transduction in neuronal, immunological, and endocrinological reactions.
TRX system and its related molecules are one of key systems to control cellular redox status, as well as the glutathione system. In the intracellular molecular network TRX plays important roles in regulating cellular signaling and gene expressions. Further analysis of the role of TRX in the oxidative stress response and the mechanism of the TRX gene regulation by oxidative stress should help to elucidate how cells link the oxidative stress response to gene regulation.
Because ROIs are involved in various diseases including not only inflammatory disease but also degenerative disease, further scrutiny is highly required.
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