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EFFECTS OF HYPOTHERMIA ON THE INDUCTION OF NO SYNTHASE EVOKED BY CYTOKINE IN VASCULAR SMOOTH MUSCLE

Research Project

Project/Area Number 11671519
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionWAKAYAMA MEDICAL COLLEGE

Principal Investigator

MAEDA Hiroshi  WAKAYAMA MEDICAL COLLEGE, DEPARTMENT OF ANESTHESIOLOGY, INSTRUCTOR, 医学部, 助手 (80199629)

Co-Investigator(Kenkyū-buntansha) HATANO Yoshio  WAKAYAMA MEDICAL COLLEGE, DEPARTMENT OF ANESTHESIOLOGY, PROFESSOR AND CHAIRMAN, 医学部, 教授 (70115913)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsVASCULAR SMOOTH MUSCLE / CYTOKINE / NO SYNTHASE / HYPOTHERMIA
Research Abstract

The purpose of this study was to clarify the effect of hypothermia on IL-1β evoked iNOS induction in vascular smooth muscle.
Exposure of rat aortic rings without endothelium to IL-1β for 5h in 37℃ Krebs Ringer solution significantly attenuated the contractile responses to phenylephrine and KCl. These attenuations were reduced when exposed to IL-1β for 5h in 27℃ Krebs Rnger solution. Exposure of the endothelium-denuded rat aorta to IL-1β for 5 h in 37℃ Krebs Ringer solution caused an increase in the tissue cGMP contents. The levels of cGMP measured in aortic strips that were exposed to IL-1β for 5h in 27℃ Krebs Ringer solution were significantly lower than those in 37℃. The expressions of iNOS mRNA and iNOS protein evoked by the exposure to IL-1β for 5h in 37℃ Krebs Ringer solution were attenuated by the exposure to IL-1β in 27℃.
The present study demonstrated that hypothermia attenuated the IL-1β evoked iNOS induction in vascular smooth muscle. These results suggest that iNOS induction may participate in the mechanism of ischemic brain damage and that the attenuation of iNOS induction may contribute the brain protection with hypothermia.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] H.Kinoshita, T.Ishikawa, Y.Hatano: "Differential effects of lidocaine and mexiletine on relaxations to ATP-sensitive potassium channel openers in rat aortas"Anesthesiology. 90. 1165-1170 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kinoshita, S.Iwahashi, T.Kakutani, K.Mizumoto, H.Iranami, Y.Hatano: "The role of endothelium-derived nitric oxide in relaxations to levcromakalim in the rat aorta"Jpn J Pharmacol. 81. 362-366 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kinoshita, T.Ishikawa, Y.Hatano: "Role of K+ channels in augmented relaxations to sodium nitroprusside induced by mexiletine in rat aortas"Anesthesiology. 92. 813-820 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 畑埜義雄,木下浩之: "摘出脳血管の反応特異性"臨床麻酔. 24. 311-325 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kinoshita, T.Kakutani, H.Iranami,Y.Hatano: "The role of oxygen-derived free radicals in augmented relaxations to levcromakalim in the aorta from hypertensive rats"Jpn J Pharmacol. 85. 29-33 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Maeda, H. Iranami, M.Yamamoto, K.Ogawa, Y.Morikawa, E.Senba, Y.Hatano: "Halothane but not isoflurane attenuates IL-1b induced nitric oxide synthase in vascular smooth muscle."Anesthesiology. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kinoshita, T.Ishikawa, Y.Hatano: "Differential effects of lidocaine and mexiletine on relaxations to ATP-sensitive potassium channel openers in rat aortas."Anesthesiology. 90. 1165-1170 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kinoshita, S.Iwahashi, T.Kakutani, K.Mizumoto, H.Iranami, Y.Hatano: "The role of endothelium-derived nitric oxide in relaxations to levcromakalim in the rat aorta."Jpn J Pharmacol. 81. 362-366 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kinoshita, T.Ishikawa, Y.Hatano: "Role of K+ channels in augmented relaxations to sodium nitroprusside induced by mexiletine in rat aortas."Anesthesiology. 92. 813-820 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Hatano, H.Kinoshita: "Isolated cerebral arteries and vascular reactivity."Jpn J Clin Anesth. 24. 311-325 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kinoshita, T.Kakutani, H.Iranami, Y.Hatano: "The role of oxygen-derived free radicals in augmented relaxations to levcromakalim in the aorta from hypertensive rats."Jpn J Pharmacol. 85. 29-33 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Maeda, H.Iranami, M.Yamamoto, K.Ogawa, Y.Morikawa, E.Senba, Y.Hatano: "Halothane but not isoflurane attenuates IL-1b induced nitric oxide synthase in vascular smooth muscle."Anesthesiology. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary

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Published: 1999-04-01   Modified: 2016-04-21  

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