Clarification on the Effects of Carbon Monoxide and Nitric Oxide and Their Control in Hepatic Sinusoid Circulation
| Project/Area Number |
11671528
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Fujita Health University |
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Principal Investigator |
KAINUMA Motoshi Fujita Health University, School of Medicine, Associate Professor, 医学部, 助教授 (90135335)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAKE Toshiyuki Fujita Health University, School of Medicine, Professor, 医学部, 教授 (40093075)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | hepatic venous hemoglobin oxygen saturation / hepatic sinusoid / carbon monoxide / nitric oxide / hepatic ischemia / liver surgery / sepsis / GST-α / 肝外傷 / エンドトキシン / ケトン体比 / 肝臓 / 肝静脈 / 周術期管理 / 麻酔 |
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| Research Abstract |
Carbon monoxide concentration, Shvo_2, GST-α and KBR were measured in patients with or without perioperative period, liver failure and multiple system organ failure. First, we measured them in 14 patients undergoing liver surgery. The relationship between hepatic venous GST-α and arterial GST-α was Y=0.69X + 8.12, R^2=0.23. The relationship between Shvo_2 and GST-α was Y==0.19X^2-27.3X+975, R^2=0.23. Therefore, GST-α significantly increased when Shvo_2 decreased. Next, we measured carbon monoxide concentration was measured in hepatic venous blood by gas mass spectrometer in 7 patients undergoing liver surgery. The relationship between O_2Hb and GOHb was Y=0.05X^2-0.0041X+1.30, R^2=0.014. There was no significant relationship. Therefore, we could not conclude whether we predict hepatic hepatic sinusoid circulation by measuring hepatic venous carbon monoxide concentration. Thirdly, we measured hepatic venous carbon monoxide concentration in 8 patients with acute liver disease. The relationship between O_2Hb and COHb was Y=0.03X^2-0.07X+4, R^2=0.007. There was no significant relationship. Fourthly, we measured nitric oxide concentrations in hepatic venous blood and on hepatic surface. The values were not stable. Fifthly, we measured them in patients under SIRS condition. The relationship between Shvo_2 and GST-α were weak, and carbon monoxide and nitric oxide concentrations varied widely, Thus we panned to measure them in animal models. We now construct data collection system with computers in experiments with septic animal models.
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Report
(4 results)
Research Products
(16 results)
