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IMMUNOLOGICAL ANALYSIS OF ANTICANCER MECHANISM TO HUMAN BLADDER CANCER OF BCG

Research Project

Project/Area Number 11671546
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionGIFU UNIVERSITY

Principal Investigator

YAMAMOTO Naoki  UNIVERSITY HOSPITAL GIFU UNIVERSITY ASSISTANT PROFESSOR, 医学部・附属病院, 講師 (10260176)

Co-Investigator(Kenkyū-buntansha) DEGUCHI Takashi  SCHOOL OF MEDICINE GIFU UNIVERSITY PROFESSOR, 医学部, 教授 (40163935)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2000: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1999: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsBCG / BLADDER CANCER / CARCINOMA IN SITU / cytotoxicity
Research Abstract

To analyze the mechanism of bovis bacillus Calmette-Guerin (BCG) against urithelial carcinoma, the following experiments were performed.
1 We demonstrated that the BCG induces maturation of human dendritic cells (DC). Surface expression of CD40, CD80, CD83, and CD86 was increased by BCG on human immature DC, and the effect was similar to those of tumor necrosis factor alpha (TNF-alpha).
2 Secretion of TNFalpha, interferon-gamma, interleukin-2 (IL-2) by BCG activated T cell was determined by intracellular cytokine staining with fluorescence-activated cell sorting (FACS) after ex vivo stimulation. Restimulation by BCG did not facilitate secretion of cytokines, .
We analysed the efficacy and safety of BCG perfusion for carcinoma in situ (CIS)
1 Treatment for CIS of the upper urinary tract, 6 patients with cytologically diagnosed CIS of the upper urinary tract were treated by BCG instillation via retrograde catheterization using a 6 F ureteric catheter or an 8 F indwelling JJ ureteric stent between the ureter and bladder. The mean follow-up was 22 months ; none of the patients died, and all were negative for cytology in urine collected from the upper urinary tracts.
2 Forty-two patients with CIS of bladder underwent intravesical instillation of BCG.In the follow-up period from 6 to 116 months, the efficacy rate of intravesical BCG instillation for CIS of the bladder was 81.0%. Two patients died from the bladder cancer. Total cystectomy was performed in 10 of 42 patients, and pathological findings of muscle layer invasion were detected in 8 patients.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Nishino Y,Yamamoto N et al: "Bacillus Calmetle-Guerin instillation for carcinoma in situ of the upper urinary troct"B J U International. 85(7). 799-801 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nishino Y,Yasuda M et al: "Bacillus Calmette-Guerin intravesical instillation treatment for carcinoma in situ of the bladder.Gifu BCG Instillation Therapy Research Group]."癌と化学療法. 26(12). 18 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nishino Y: "Bacillus calmette-Guerin instillation for carcinoma in situ of the upper urinary trad"BJU Int. 85(7). 799-801 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nishino Y: "Bacillus calmette-Guerin intravesiral instillation treatment for carcinoma in situ of the bladder"Gan to Kagaku Ryoho. 26(12). 1869-73 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nishino Y,Yamamoto N et al: "Bacillus Calmette-Guerin instillation treatment for carcinoma in situ of the upper urinary tract."BJU International. 85(7). 799-801 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nishino Y,Yasuda M,Yoko S,Ehara H,Yamanoto N et al: "Bacillus Calmette-Guerin intravesical instillation treatment for carcinoma in situ of the bladder. Gif BCG Instillation Therapy Research Group."癌と化学療法. 26・12. 1869-1873 (1999)

    • Related Report
      2000 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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