| Co-Investigator(Kenkyū-buntansha) |
KOHRI Kenjiro NAGOYA CITY UNIVERSITY, Medical School, Professor, 医学部, 教授 (30122047)
KUNIMATSU Mitoshi NAGOYA CITY UNIVERSITY, Medical School, Assistant Professor, 医学部, 講師 (70145746)
TOZAWA Keiichi NAGOYA CITY UNIVERSITY, Medical School, Assistant Professor, 医学部, 講師 (40264733)
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| Budget Amount *help |
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Research Abstract |
It was examined from two directions in the elucidation of bone specific metastasis of the prostatic cancer. From the fact that the prostatic cancer is the androgen dependent cancer and breast cancer is dependent on female sex hormone, one is the speculation that the sex hormone may be concerned in bone specific metastasis. Next, it is the speculation that the contributor which shows the specific bone metastasis of prostatic cancer regardless of the sex hormone may exist in tgne bone.
In the first speculation, the following were made to be the basic model : Rat of male and famale which did sex maturation and rat of male and famale of the sex immaturity. Those bone marrow were extracted, and adhesion grade of prostatic cancer cell line was examined. As the result, prostatic cancer cell did not show the adhesion to the bone marrow extract of the male rat which did sex maturation in it of scalpel rat that it showed the resistant adhesion and did the sex maturation and male and famale rat of
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the sex immaturity. And, though in the model which took the testosterone to the scalpel rat, the blood testosterone increased, also the prostatic cancer cell did not show the adhesion in the bone marrow extract. It is considered that in the bone marrow extract of the male rat which did the above approach sex maturation, the material concerning the prostatic cancer bone peculiar transition in which even if, the testosterone value does not appear even in the high value in bone marrow of the scalpel rat in the existence exists. In the meantime, bone marrow extract of the male rat was divided by the chromatography, and the fractionation which showed prostatic cancer culture cell and adhesion most was decided. It was proven to be the hemoglobin with that the amino acid sequence and molecular weight are examined. Hemoglobin itself are large some materials in the human body, and there is the resistance in order to specify with the contributor of the bone peculiar transition. However, the some materials in which part of the structure and part of amino acid sequence agreed existed in the bone marrow, and it seemed to be possible to be one of the contributors of the prostatic cancer bone peculiar transition. Less
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