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Investigation of cancer growth factors in hormone refractory prostate cancer.

Research Project

Project/Area Number 11671585
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionNippon Medical School

Principal Investigator

KIMURA Go  Nippon Medical School, Dept. of Urology, Associate Professor, 医学部, 助教授 (20234354)

Co-Investigator(Kenkyū-buntansha) KONDO Yukihiro  Nippon Medical School, Dept. of Urology, Associate Professor, 医学部, 助教授 (80215467)
秋元 成太  日本医科大学, 医学部, 教授 (50089752)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsProstate cancer / growth factor / androgen / hormone refractory
Research Abstract

1. The examination of prostata specific antigen (PSA) molecular form and pathological characteristics in the prostatic cancer patient.
There is the usefulness of serum PSA (total) in the diagnosis of the prostatic cancer. We examined PSA molecular form such as free PSA or free/total PSA ratio connective (PSA-ACT) to α 1-antichymotrypsin in prostate cancer. The usefulness of adjusted for PSA with prostate gland volume or transition zone volume Density (PSAD) or the transition zone volume (PSATZD) is also examined. The correlation was recognized at adjusted for the transition zone volume (PSATZD).
2. The examination of prostate gland conversion division volume and pathological characteristics in the prostatic cancer patient.
Then, the inverse correlation relation was recognized in volume and Gleason score in the conversion division, when prostate gland total extirpation sample and conversion division volume on the ultrasonic wave in the biopsy and Gleason score were examined.
3. The examination in the prostatic cancer in operation sample of growth factor.
The localization and dyeability were contrasted with the histopathological image of prostatic cancer by doing the immune tissue dyeing using the growth factor antibody including growth factor that it is the insulin in prostate gland total extirpation sample. It tended to do low intensity of each growth factor in carcinoma tissue and the circumference the result which the prostate gland conversion division volume was big as the result, and there was. The possibility of working unlike the growth factor of cancer cell rather inhibitory was indicated the factor which increased the conversion division volume from the above result.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Osawa,S.Terashima,Y Kimura,G.Akimoto,M: "Antitumor effects of the angiogenesis inhibitor AGM-1470 on rat urinary bladder tumor in duced by N-butyl-N-(4-hydroxybtyl) nitrosanine"British Journal of Urology. 83. 123-128 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kondo,Y.Yanagiya,T et. al: "Simian virus 40-transformed metallo thionein null cells showed increased sensitivity to cadmium but reat to ginc, copper, mereay or nickel."Life Science. 68. 177-182 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nemoto.K,Kondo.Y.Hinemo,S. et. al: "Modulation of telome rase activity by zinc in human prostatic and renal cancer cells."Biochemicol Pharmacology. 59. 401-405 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kondo,Y Himeno,S. et. al.: "Metallo thionein modulates the carcinogenicity of N-butyl-N-(4-hydroxybutyl) nitrosamine in mice."Carcinogenesis. 20. 1625-1628 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hattori,T.Kimara,G. et. al: "The efficacy of Baullus Culnette Guerin instillation therapy of the upper urinary tract for carcinoma in situ."International Journal of Clinical Oncology. 4. 295-297 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Susulei,Y.Kondo,Y et. al: "Role of Antioxidant Systems in Human Androgen Independent Prostate Cancer Cells"Prostate. 43. 144-149 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Osawa, S., Terashima, Y., Kimura, G.and Akimoto, M.: "Antitumor effects of the angiogenesis inhibitor AGM-1470 on rat urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine."British Journal of Urology. 83. 123-128 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kondo, Y., Yanagiya, T., Himeno, S., Yamabe, Y., Schwartz, D., Akimoto, M., Lazo, J.S.and Imura, N.: "Simian virus 40-transformed metallothionein null cells showed increased sensitivity to cadmium but not to zinc, copper, mercury or nickel."Life Science. 64. 145-150 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yanagiya, T., Imura, N, Kondo Y.and Himeno, S.: "Reduced uptake and enhanced release of cadmium in cadmium-resistant metallothionein null fibroblast."Life Science. 65. 177-182 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sakurai, A., Hara, S., Okano, N., Kondo Y., Inoue, J.and Imura, N.: "Regulatory role of metallothionein in NF-kB activation."FEBS Letter. 455. 55-58 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nemoto, K., Kondo, Y., Himeno, S., Suzuki, Y.Hara, S., Akimoto, M and Imura, N.: "Modulation of telomerase activity by zinc in human prostatic and renal cancer cells."Biochemical Pharmacolgy. 59. 401-405 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kondo, Y., Himeno, S., Endo, W., Mita, M., Suzuki, Y., Nemoto, K., Akimoto, M., Lazo, J.S.and Imura, N.: "Metallothionein modulates the carcinogenicity of N-butyl-N-(4-hydroxybutyl) nitrosamine in mice."Carcinogenesis. 20. 1625-1628 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hattori, T., Kimura, G., Horiuch, K., Tsuboi, N., Yoshida, K.and Akimoto, M.: "The efficacy of Bacillus Calmette Guerin instillation therapy of the upper urinary tract for carcinoma in situ."International Journal of Clinical Oncology. 4. 295-297 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Watari, Y., Stoh, H., Matsubara, M., Asakawa, K., Kamaguchi, H., Nagai, S., Murase, Y., Yokoyama, M., Kimura, G., Tamura, K.and Sugisaki, Y.: "Comparison of urine cytology between the ileal conduit and Indiana pouch."Acta.Cytologia. 44. 748-751 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Suzuki, Kondo Y, S.Himeno, K.Nemoto, M.Akimoto and Imura N.: "Role of Antioxidant Systems in Human Androgen-Independent Prostate Cancer Cells."Prostate. 43. 144-149 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Watarai,Y.Satoh,M. et.al.: "Comparison of uring cytology betwear the ileal conduit and indiana pouch."Acta Cytolgica. 44. 748-751 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hattori,T.Kimura,G.Horiucl,K. et al.: "The efficacy of Bacillus Calaette-Guerin instillation therapy of the upper urinary trad for carcinoma in rate."International Journal of Clinical Oncology. 4. 295-297 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Horinch,C.Tsboi,N. et.al: "High-freguenoy enblumind ultresonography for staging transitional cell carcinoma of the bladder"Urology. 56. 404-407 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tsuboi,P.Horiach,K.Kimura,G et.al.: "Read masses detected by Senegal lenlth ched-up"International Journal of Urology. 7. 404-408 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yukihiro Kondo: "Simian virus 40-transformed metallothionein null cells showed increased sensitivity cadmium but not to zinc , copper, mercury or nickel."Life Science. 64. 145-150 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takehiro Kondo: "Reduced uptake and enhanced release of cadmium in cadmium resistante metallothionein null fibroblast"Life Science. 65. 177-182 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yukihiro Kondo: "Metallothionein modulates the carsinogenicity of N-batyl-N(4-hydroxybutyl)nitrosamine in mice"Carcino genesis. 20. 1625-1627 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Atusko Sakurai: "Regulatory role of metallothionein in NF-K13 activation"FEBS Letters. 455. 55-58 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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