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Maternal immune system which cotribute to the maintenance of pregnancy in the decidua

Research Project

Project/Area Number 11671601
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY

Principal Investigator

SAITO Shigeru  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY Medical Obstetrics and Gynecology Professor, 医学部, 教授 (30175351)

Co-Investigator(Kenkyū-buntansha) TSUDA Hiroshi  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY Medical Obstetrics and Gynecology assistant, 附属病院, 助手 (80293314)
TANEBE Kyoko  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY Medical Obstetrics and Gynecology assistant, 医学部, 助手 (90303239)
SAKAI Masatoshi  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY Medical Obstetrics and Gynecology assistant, 医学部, 助手 (90242502)
MICHIMATA Toshihiko  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY Medical Obstetrics and Gynecology assistant, 附属病院, 助手 (90281021)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsTh1 / Th2 / decidua / pregnancy / preeclampsia / cytokine / 免疫
Research Abstract

It has been demonstrated that pregnancy induces the immunomodulation of cytokine responses away from Th1 paradigm and towards the Th2 paradigm. In this study, we demonstrated that the percentage of Th1 cells was lowest the decidua in early pregnancy and highest in endometrium during the proliferative phase followed by endometrium in the secretory phase. On the other hand, the percentage of Th2 cells was highest in the decidua in early pregnancy and lowest in the endometrium during the proliferative phase. We further demonstrated that not only Th2 cells but also Tc2 cells increased in the early pregnancy decidua. These results indicate the significance of Th2- and Tc2- type cells of the decidua in the maternal system, presumably through their production of cytokines which may contribute to the maintenance of pregnancy. We further studied the Th1/Th2 balance in abnormal pregnancy state preeclampsia. We found that Th2 cells were predominated in peripheral blood in the second and third trimester of normal pregnancy, Th1 cells predominated in preeclamptic patients. And we demonstrated that IL-12 production by monocytes regulates Th1/Th2 balance not only in normal pregnancy but also in preeclampsia. Our data suggest that Th2 dominant immune state contribute the maintenance of pregnancy and the disturbance of this delicate balance might result in abnormal pregnancy ; ie recurrent abortion and preeclampsia.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Tsuda H. et al.: "Characterization of NKT cells in human perpheral blood and decidual lymphocytes."Am.J.Reprod.Immunol.. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Saito S.: "Cytokine cross-talk between mother and the embryo/placenta."J.Reprod.Immunol.. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tsuda H. et al.: "A novel surface molecule of Th2-and Tc2-type cells, CRTH2 expression on human peripheral and decidual CD4^+ and CDS^+T cells during the early stage of pregnancy."Clin.Exp.Immunol.. 123・1. 105-111 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Saito S.: "Cytokine netwrok at feto-maternal interface."J.Reprod.Immunol.. 47・2. 87-103 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Luo L. et al.: "Interleukin-8 levels and granulocyte counts in cervical mucus during pregnancy."Am.J.Reprod.Immunol.. 43・1. 78-84 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Saito S. et al.: "Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1 : Th2 cell ratio during normal human pregnancy and preeclampsia."Clin.Exp.Immunol.. 117・3. 550-555 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Saito S.(Editor Gupta S.K.): "Reproductive Immunol."Narosa Publishing House. 401 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 齋藤滋 他(中野實,荒木慶彦 編): "哺乳類の生殖化学-マウスからヒトまで-"アイピーシー. 527 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Saito S., Sakai M., Sasaki Y., Tanebe K., Tsuda H., Michimata T.: "Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1 : Th2 cell ratio during normal human pregnancy and preeclampsia."Clin. Exp. Immunol.. 117. 550-555 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Luo L., Ibaragi T., Maeda M., Nozawa M., Kasahara T., Sakai M., Sasaki Y., Tanebe K.and Saito S.: "Interleukin-8 levels and granulocyte counts in cervical mucus during pregnancy."Am.J.Reprod.Immunol.. 43. 78-84 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Saito S.: "Cytokine network at fetomaternal interface."J.Reprod.Immunol.. 47. 87-103 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tsuda H., Michimata T., Sakai M., Nagata K., Nakamura M.and Saito S.: "A novel surface molecule of Th2- and Tc2-type cells, CRTH2 expression on human peripheral and decidual CD4^+ and CD8^+ T cells during the early stage of pregnancy."Clin.Exp.Immunol.. 123. 105-111 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shigeru Saito: "Cytokine cross-talk between mother and the embryo/ placenta <Review>."J.Reprod.Immunol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tsuda H., Sakai M., Michimata T., Tanebe K., Hayamawa S.and Saito S.: "Characterization of NKT cells in human peripheral blood and decidual lymphocytes."Am.J.Reprod.Immunol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Saito S.: "Cytokine network in the human decidua."Reproductive Immunology Gupta S.K.(Ed) Norosa Publishing House, New Delhi, India. 78-87 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tsuda H. et al.: "Characterization of NKT cells in human perpheral blood and decidual lymphocytes."Am.J.Reprod.Immunol.. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Saito S.: "Cytokine cross-talk between mother and the embryo/placenta."J.Reprod.immunol.. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tsuda H. et al.: "A novel surface molecule of Th2- and Tc2-type cells, CRTH2 expression on human peripheral and decidual CD4^+ and CD8^+ T cells during the early stage of pregnancy."Clin.Exp.Immunol.. 123・1. 105-111 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Saito S.: "Cytokine network feto-maternal interface"J.Reprod.Immunol.. 47・2. 87-103 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Luo L. et al.: "Interleukin-8 levels and granulocyte counts in cervical mucus during pregnancy."Am.J.Reprod.Immunol.. 43・1. 78-84 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Saito S. et al.: "Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1 : Th2 cell ratio during normal human pregnancy and preeclampsia."Clin.Exp.Immunol.. 117・3. 550-555 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Saito S.(Editor Gupta S.K.): "Reproductive Immunol."Narosa Publishing House. 401 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 齋藤滋 他(中野實,荒木慶彦編): "哺乳類の生殖生化学-マウスからヒトまで-"アイピーシー. 527 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Saito, S. et al.: "Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia."Clin. Exp. Immunol.. 117. 550-555 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Saito, S. et al.: "Distribution of Th1, Th2, and Th0 and the Th1/Th2 cell ratios in human peripheral and endometrial T cells."Am. J. Reprod. Immunol.. 42. 240-245 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Saito, S. et al.: "Increased T-helper-1-type immunity and decreased T-helper-2-type immunity in patients with preeclampsia."Am. J. Reprod. Immunol.. 41. 297-306 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Luo, L.. et al.: "Interleukin-8 levels and granulocyte counts in cervical mucus during pregnancy."Am. J. Reprod. Immunol.. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Skakura, et al.: "Stimulation of DNA synthesis in trophoblasts and human umbilical vein endotherial cells by hepatocyte growth factor bound to extracellular matrix."Placenta. 20. 683-693 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Gupta S. K.: "Reproductive Immunology"Norosa Publishing House, New Delhi,. 401 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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