| Project/Area Number |
11671646
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Saitama Medical School |
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Principal Investigator |
TAKADA Satoru Saitama Medical School, School of Medicine, Professor, 医学部, 教授 (20143456)
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| Co-Investigator(Kenkyū-buntansha) |
SAITOH Maki Saitama Medical School, School of Medicine, assistant, 医学部, 助手 (20301468)
OHKUBO Takashi Saitama Medical School, School of Medicine, assistant, 医学部, 助手 (40271241)
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| Project Period (FY) |
1999 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1999: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | endomentrium / trophoblast / desidualization / cytokine / TNF / thymidine phosphorylase / VEGF / prostaglandin / TNFd / apoptosis / IL-6 / IL-8 / 妊娠中毒症 / 絨毛細胞 / 脱落膜 / ステロイド受容体 / マクロファージ / PGE_2 / decidual cell / trophoblast / thymidine phosphovylase / cytokine / prostaglandin |
|---|
| Research Abstract |
Development of the placenta and decidualizing process is clearly influenced by cells and products of the immune system at the feto-material interface after implantation. Topograplucal and temporal differences in both the growth and differentiation of endometrial elements suggest that local autocrine and paracrine factors modulate the effects of sex steroids. In a previous study, we demonstrated to establish a permanent endometrial stromal fibroblast cell line and a trophoblast cell line. Here we have investigated decidualizing mechanisms and cell-cell interactions at the feto-material interface, using these cell lines.
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