| Project/Area Number |
11671655
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | NIPPON MEDICAL SCHOOL |
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Principal Investigator |
YONEYAMA Yoshio NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (00201096)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Shunji NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (80291722)
SAWA Rintaro NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (30267174)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | adenosine / fetus / tumor necrosis factor / 脳児 / アデノシン / TNF-α / エンドドキシン / 胎児 / エンドトキシン / lipopolysaccharide |
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| Research Abstract |
[PURPOSE] The purpose of this study is to evaluate the inhibitory effect of fetal adenosine on production of tumor necrosis factor-α(TNF-α).
[METHOD] We measured plasma adenosine and TNF-α concentrations in the fetuses and preeclamptic women, and then evaluate the relationship between them.
[RESULTS] The elevation of plasma adenosine was associated with the inhibitory effect of production of TNF-α.
[CONCLUSION] This study has suggested that plasma adenosine may play role in the regulation of TNF-α, which eventually dampens to worsen the pathologic conditions of fetuses and preeclamptic women.
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