| Project/Area Number |
11671662
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kurume University |
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Principal Investigator |
SUGIYAMA Toru School of Medicine, Associated Professor, 医学部, 助教授 (40162903)
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| Co-Investigator(Kenkyū-buntansha) |
USHIJIMA Kimio School of Medicine, Lecture, 医学部, 講師 (20185002)
NISHIDA Takashi School of Medicine, Professor, 医学部, 教授 (70140712)
KAMURA Toshiharu School of Medicine, Professor, 医学部, 教授 (30152870)
KUMAGAI Seisuke School of Medicine, 医学部, 助手 (20289474)
MURAKAMI Fumihiro School of Medicine, 医学部, 助手 (90289471)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2001: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1999: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | ovarian cancer / chemotherapy / paclitaxel / CPT-11 / cytotoxic effect / drug resistance / molecular biclogy |
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| Research Abstract |
1.Experimental Chemotherapy : Sequential therapy with carboplatin, paclitaxel, and CPT-11 was performed for rat primary ovarian cancer. No macroscopic differences.in anti-tumor effects were observed, suggesting limitations of this sequential therapy in treatment of clinical cases, although some issues, such as selection of adequate doses, remain to be further investigated.
2.Jnhibitory effect of an anti-vascularization inhibitor on tumor viability : Although an anti-vascularization inhibitor (FNP-470)was administered to rat neonates 7 days after intraperitoneal administration of DMBA-OC-1 (cell line), tumor viability did not differ between the control group (25/31, 80.6%) and the TNP-470-treated group (26/36, 72.2 %). The number of new blood vessels was identical between the two groups at microangiography. This experimental model was thought to correspond to clinical micro-residual cases. However, use of some concomitant drug(s) with TNP-470 seemd to be required, because it was suggested that TNP-470 bad difficulty in inhibiting vascularization when used, alone.
3.Clinical Study : The response rate of CPT-11/CDDP was 40% (33% for patients with resistant disease). Activity of topoisomerase-1 significantly increased in the responding cases, compared with the non-responding cases, indicating a possibility that treatment can be performed using this activity as a target. Paclitaxel showed low toxicity and effectiveness when administered weekly (sensitive : 3/4, resistant : 1/6).. No responding cases with resistant disease were observed in the treatment with dcetaxel/CPT-11.Four often cases with sensitive disease (40%) responded to docetaxel/carboplatin. In 11 of 24 frozen-stored clinical specimens (45.8%), p53 mutation was detected. Thus this mutation has been continuously studied at the present time, in relation tq clinical efficacy. Because all. 24 cases examined were negative for c-erbB-2, indications of herceptin were thought to be very limited.
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