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SPECT evaluation of regional cerebral activation during electrical auditory stimulation in profoundly deal patients

Research Project

Project/Area Number 11671691
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionMiyazaki Medical College

Principal Investigator

TONO Tetsuya  Miyazaki Medical College, Otorhinolaryngology, Associate Professor, 医学部, 助教授 (80145424)

Co-Investigator(Kenkyū-buntansha) JINNOUCHI Seishi  Miyazaki Medical College, Radiology, Associate Professor, 医学部, 助教授 (60154423)
TAKENAKA Mika  Miyazaki Medical College, Otorhinolaryngology, Associate, 医学部, 助手 (80315374)
USHISAKO Yasuaki  Miyazaki Medical College, Otorhinolaryngology, Associate, 医学部, 助手 (10185001)
NAGAMACHI Shigeki  Miyazaki Medical College, Radiology, Assistant Professor, 医学部, 講師 (40180517)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsCochlear implants / Regional cerebral blood flow / Single photon emission computed tomography / Electrical auditory stimulation / Auditory cortex / Auditory rehabilitation / 脳機能画像 / 人工内耳 / 脳血流 SPECT
Research Abstract

Electrical promontory stimulation test has been used for preoperative functional evaluation of the auditory nerve in cochlear implant candidates. However, due to the lack of an objective information on cortical integration, results of this test do not seem to predict what extent the cochlear implant will be successful.
An attempt was made to employ the single photon emission computed tomography (SPECT) to evaluate a possible change in the regional cerebral blood flow (rCBF) in the central auditory areas during electrical stimulation. A statistically significant increase in rCBF was detected in the temporal lobe in profoundly deaf adult patients. Discrepancy between subjective auditory sensation and rCBF changes in response to electrical stimulation may limit the potential usefulness of SPECT in preoperative evaluation of the cortical integration in cochlear implant candidates. However a significant activation of the auditory cortex detected in 2 cases with central nerve diseases encouraged both patients and surgeons for cochlear implantation. Further studies including pre- and postoperative tests using rCBF SPECT should be helpful to determine the mechanism of sound integration in profoundly deaf patients involving central auditory pathways.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Ushisako Y: "Regional cerebral activation during auditory stimulation in a patient with binaural cochlear implants using 99m Tc-ECD SPECT"Adv Oto Rhino Iaryngol. 57. 63-66 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tono T: "Clinical experience with partially implantable middle ear implant"Adv Oto Rhino Iaryngol. 57. 186-188 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kiyomizu K: "Dizziness and vertigo after cochlear implantation"Adv Oto Rhino Iaryngol. 57. 173-175 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 東野哲也: "x中枢病変を伴った例に対する人工内耳-脳血流SPECTを用いた適応検査とクラリオンS使用経験-"耳鼻と臨床. 48. 120-125 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tono T: "Cochlear implants"Kugler, Hague. 599 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ushisako Y: "Regional cerebral activation during auditory stimulation in a patient with binaural cochlear implants using 99 m Tc-ECD SPECT"Adv Oto Rhino laryngol. 57. 63-66 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tono T: "Clinical experience with partially implantable middle ear implant"Adv Oto Rhino laryngol. 57. 186-188 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kiyomizu K: "Dizziness and vertigo after cochlear implantation"Adv Oto Rhino laryngol. 57. 173-175 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takenaka M: "Comparison between promontory and tympanic electrodes in electrical auditory stimulation"Cochlear implant, Kubo T, Takahashi Y, Iwaki T (ed). (Kugler, Hague). 79-81 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tono T: "Results of tympanoplasty for chronic otitis media in cochlear implant candidates"Cochlear implants, Kubo T, Takahashi Y, Iwaki T (ed). (Kugler, Hague). 237-239 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ushisako Y: "Speech discrimination in post-lingually deaf adult patients using SPECTRA 22"Cochlear implants, Kubo T, Takahashi Y, Iwaki T (ed). Kugler Hague. 479-482 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tono, T. et al.: "Different clinical chracteristics of aminoglycoside-induced profound deafness with and without the 1555 A->G mitochondrial mutation"ORL. 63. 25-30 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 東野哲也, 他: "迷路骨化例に対する人工内耳手術の問題点"頭頸部外科. 11. 53-60 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 東野哲也: "成人人工内耳手術法"ENTONI. 1. 37-42 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 東野哲也: "新生児・幼児・小児の難聴"文光堂. 254 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 東野哲也: "急性高度難聴・症例の人工内耳成績"Audiology Japan. 43. 118-123 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kawano H: "Petrous high jugular bulb : A histological Study."Am J Otolaryngol. 21. 161-168 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tono T: "Different clinical characteristics of aminoglycoside-induced profound deafness with and without the 1555A→G mitochondrial mutation."ORL. 665(in press). (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ushisako Y: "Adv Oto Rhino Laryngol 57"Regional cerebral activation of during auditory Stimulation in a Patient with binaural cochlear implants using ^<99m> Tc-ECD SPECT.. 459 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tono T: "Adv Oto Rhino Laryngol 57"Clinical experience with partially implantable middle ear implant.. 459 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 鍋倉 隆: "突発性難聴再発例の蝸電図所見"Audiology Japan. 42. 211-216 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 東野 哲也: "人工中耳の経験とその術後成績"日本耳鼻咽喉科学会会報. 102. 835-845 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 清水 謙祐: "人工内耳症例における術後めまいの検討"Otology Japan. 9. 588-593 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 東野 哲也: "急性高度難聴症例の人工内耳成績"Audiology Japan. (掲載予定).

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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