| Project/Area Number |
11671693
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kagoshima University |
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Principal Investigator |
KURONO Yuichi (2000) Faculty of Medicine, Kagoshima University, Professor, 医学部, 教授 (80153427)
河野 もと子 (1999) 鹿児島大学, 医学部, 助手 (70295252)
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| Co-Investigator(Kenkyū-buntansha) |
DEGUCHI Kouji University Hospital, Faculty of Medicine, Kagoshima University, Research Associate, 医学部・附属病院, 助手 (50315438)
MIYANOHARA Ikuyo University Hospital, Faculty of Medicine, Kagoshima University, Assistant Professor, 医学部・附属病院, 講師 (40305131)
MATSUNE Shoji Faculty of Medicine, Kagoshima University, Associate Professor, 医学部, 助教授 (00253899)
NISHIMOTO Kengo University Hospital, Faculty of Medicine, Kagoshima University, Research Associate, 医学部・附属病院, 助手 (50305132)
黒野 祐一 鹿児島大学, 医学部, 教授 (80153427)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | nasal allergy / helper T cell / Th2 / Th1 / cytokine profile / therapeutic effect / ヘルパーT細胞 |
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| Research Abstract |
By use of flow cytometry, we detected the intracellular cytokine of T cells, IL-4 and TNF-α, in peripheral blood and palatine tonsil from the patients with allergic rhinitis. In addition, we investigated the therapeutic effect to the rate of Th2/Th1 using anti-allergic agents, suplatast tosilat The suplatast tosilate is known that the agents which will normalize the Th2/Th1 unbalance.
The results showed that the rate of Th2/Th1 from the patients with nasal allergy was higher than that from healthy control in peripheral mononuclear cells and tonsillar mononuclear cells, but there was no statistical significant.
There was no definite therapeutic effect on the rate of Th2/Th1 in the peripheral mononuclear cells from the patients with nasal allergy after short-term using suplatast tosilate. But some cases who were clinically effective to the suplatast tosilate the rate of Th2/Th1 was reduced after using of suplatast tosilate.
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