| Project/Area Number |
11671707
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | TOKYO WOMEN'S MEDICAL UNIVERSITY |
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Principal Investigator |
ARAI Yasuko Tokyo Women' s Medical University assistant professor, 医学部, 助教授 (50119880)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIDA Motoko Tokyo Women' s Medical University, assistant, 医学部, 助手 (60297554)
UEDA Noriko Tokyo Women's Medical University, assistant, 医学部, 助手 (50232757)
石井 香澄 東京女子医科大学, 医学部, 助手 (20256580)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | caloric nystagmus / three dimension analysis / semicircular canal plugging / post-rotatory nystagmus / non-invasive measurement / cinomolgus monkeys / pigeon / reconstruction of membranous labyrinth / 神経切断実験 / 頭振 / 非侵襲的 / サル |
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| Research Abstract |
The head investigator Arai found that three dimension analysis of normal and selective canal plugged caloric nystagmus in monkeys suggested gravitational orienting other than convection, and that semicircular canal plugging did not abolish caloric nystagmus. In order to explain these phenomena, Arai performed present project.
Arai analyzed three dimension caloric nystagmus in different head positions relative to gravity from normal and all 6-semicircular-canal plugged monkeys. This revealed (1) close correlation of the orientation of nystagmus between head vertical component and earth vertical component, (2) convection current in the canals was lost after plugging , (3) position dependency of the amount of response was also lost after plugging. Hystrological examination of one animal showed boney occlusion of the membranous canals with intact sensory cells. Arai explained caloric nystagmus as the summated response.of (1) thermal convection which is lost after plugging, (2) cooling of all of the canal nerves, (3) pressure effect by thermal volume change which is enhanced after plugging canals, and (4) otolith orientation via velocity storage. Model based approach for the all canal plugged caloric response fitted to the actual responses.
Three dimensional reconstruction of the membranous labyrinth from the serial section of the monkeys' bilateral temporal bones was almost finished by Uoda.
Nishida established non invaisive, non restricted measurements of the head rotation in pigeons, using two synchronous video movies.
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