| Project/Area Number |
11671710
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
WATANABE Shoji St. Marianna University School of Medicine, M.D., 医学部, 助手 (00257396)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Tadashi Yamagata University, School of Medicine, associated doctor, 医学部, 助教授 (10125776)
加藤 功 聖マリアンナ医科大学, 医学部, 教授 (90018375)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | optokinetic nystagmus / nucleus of the optic tract / monkey / lateral nucleus of accessory optic system / 前庭眼反射 / 適応現象 / 視覚-前庭矛盾刺激 |
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| Research Abstract |
The nucleus of the optic tract (NOT), an important visuo-motor relay between the retina and preoculomotor structures, is responsible for mediating horizontal optokinetic nystagmus (OKN) in monkeys, cats, rabbits and rats. In addition to its projection to the vestibular nuclei, the NOT has a prominent projection to the contralateral NOT via the posterior commissure. In order to evaluate the role of the commissural fibers between the NOTs in OKN, we cut the posterior commissure in three Macaca fuscata. [Results] (1) The gain reduction in the rapid rise and steady state slow-phase velocity of OKN can be explained by removal of an excitatory signal mediated by commissural fibers to the inhibitory interneurons in the contralateral NOT. However, interrupting the commissural fibers has noihing to do with the velocity storage mechanism, because time-constants of OKAN mostly remained unchanged by the lesion. (2) The lesions of the lateral nucleus of accessory optic system (LTN) abolished the nystagmus with slow-phase toward-up. The horizontal OKN toward lesioned side were developed well. The LTN may be responsible for not the vertical OKN but also horizontal OKN.
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